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Article

Enhancement of Antimicrobial and Antiproliferative Activities of Standardized Frankincense Extract Using Optimized Self-Nanoemulsifying Delivery System

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Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt
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Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt
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Department of Microbiology and Immunology, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt
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Department of Pharmacognosy, School of Pharmacy, Newgiza University, Giza 12556, Egypt
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Department of Pharmacology and Toxicology, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt
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Author to whom correspondence should be addressed.
Academic Editor: Bruno Sarmento
Sci. Pharm. 2021, 89(3), 36; https://doi.org/10.3390/scipharm89030036
Received: 3 June 2021 / Revised: 25 July 2021 / Accepted: 28 July 2021 / Published: 2 August 2021
Boswellic acids (BAs) are the main bioactive compounds of frankincense, a natural resin obtained from the genus Boswellia. This study aimed to develop a self-nanoemulsifying delivery system (SNEDS) to improve the antimicrobial and antiproliferative activities of standardized frankincense extract (Fr-extract). Fr-extract was standardized, and BA content was quantified using the developed HPLC-UV method. Screening studies of excipients followed by formula optimization using a mixture simplex lattice design was employed. The optimized Fr-SENDS formulation was characterized. Furthermore, microbiological and antiproliferative assessments of the standardized Fr-extract and Fr-SNEDS were evaluated. Quantification demonstrated that the major constituent is 11-keto-boswellic acid (KBA) (16.25%) among BA content (44.96%). The optimized Fr-SENDS (composed of 5% CapryolTM 90, 48.7% Gelucire® 44/14 and 46.3% ethanol) showed spherical nanosized dispersions with DS, PDI, and zeta potential of 17.9 nm, 0.2, and −14.5 mV, respectively. Fr-SNEDS exhibited lower MIC and MBC values compared with Fr-extract against pathogens conjugated with lung cancer and was comparable to reference antimicrobials. Fr-SNEDS showed superior antiproliferative activity over Fr-extract, with IC50 values of 20.49 and 109.5 μg mL−1, respectively. In conclusion, the optimized Fr-SNEDS could be easily developed and manufactured at a low cost and the in vitro results support its use as a potential adjuvant oral therapy for lung cancer. Further in vivo studies could be continued to assess the therapeutic efficiency of the prepared system. View Full-Text
Keywords: antiproliferative; boswellic acids; frankincense; MRSA; self-nanoemulsifying delivery system; simplex lattice design antiproliferative; boswellic acids; frankincense; MRSA; self-nanoemulsifying delivery system; simplex lattice design
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MDPI and ACS Style

El-Mancy, S.S.; El-Haddad, A.E.; Alshareef, W.A.; Saadeldeen, A.M.; El-Emam, S.Z.; Elnahas, O.S. Enhancement of Antimicrobial and Antiproliferative Activities of Standardized Frankincense Extract Using Optimized Self-Nanoemulsifying Delivery System. Sci. Pharm. 2021, 89, 36. https://doi.org/10.3390/scipharm89030036

AMA Style

El-Mancy SS, El-Haddad AE, Alshareef WA, Saadeldeen AM, El-Emam SZ, Elnahas OS. Enhancement of Antimicrobial and Antiproliferative Activities of Standardized Frankincense Extract Using Optimized Self-Nanoemulsifying Delivery System. Scientia Pharmaceutica. 2021; 89(3):36. https://doi.org/10.3390/scipharm89030036

Chicago/Turabian Style

El-Mancy, Shereen S., Alaadin E. El-Haddad, Walaa A. Alshareef, Amr M. Saadeldeen, Soad Z. El-Emam, and Osama S. Elnahas 2021. "Enhancement of Antimicrobial and Antiproliferative Activities of Standardized Frankincense Extract Using Optimized Self-Nanoemulsifying Delivery System" Scientia Pharmaceutica 89, no. 3: 36. https://doi.org/10.3390/scipharm89030036

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