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Open AccessReview

Porophyllum Genus Compounds and Pharmacological Activities: A Review

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Área Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Av. Universidad Km 1, Ex-Hda. de Aquetzalpa, Tulancingo 43600, Mexico
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Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex Hacienda la Concepción s/n, San Agustín Tlaxiaca 42160, Mexico
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Área Académica de Química de Alimentos, Instituto de Ciencias Básicas e Ingenierías, Universidad Autónoma del Estado de Hidalgo, Pachuca-Tulancingo km 4.5 Carboneras, Pachuca de Soto 42184, Mexico
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Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1., Centro, Xochitepec 62790, Mexico
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Authors to whom correspondence should be addressed.
Sci. Pharm. 2021, 89(1), 7; https://doi.org/10.3390/scipharm89010007
Received: 9 December 2020 / Revised: 6 January 2021 / Accepted: 7 January 2021 / Published: 18 January 2021
The genus Porophyllum (family Asteraceae) is native to the western hemisphere, growing in tropical and subtropical North and South America. Mexico is an important center of diversification of the genus. Plants belong of genus Porophyllum have been used in Mexican traditional medicine to treat kidney and intestinal diseases, parasitic, bacterial, and fungal infections and anti-inflammatory and anti-nociceptive activities. In this sense, several trials have been made on its chemical and in vitro and in vivo pharmacological activities. These studies were carried on the extracts and isolated compounds and support most of their reported uses in folk medicine as antifungal, antileishmanial, anti-inflammatory, anti-nociceptive and burn repair activities, and as a potential source of new class of insecticides. Bio guided phytochemical studies showed the isolation of thiophenes, terpenes and phenolics compounds, which could be responsible for the pharmacological activities. However, more pre-clinical assays that highlight the mechanisms of action of the compounds involved in pharmacological function are lacking. This review discusses the current knowledge of their chemistry, in vitro and in vivo pharmacological activities carried out on the plants belonging to the Porophyllum genus. View Full-Text
Keywords: Porophyllum; phytochemical studies; bioactive compounds; pharmacological activities Porophyllum; phytochemical studies; bioactive compounds; pharmacological activities
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MDPI and ACS Style

Vázquez-Atanacio, M.J.; Bautista-Ávila, M.; Velázquez-González, C.; Castañeda-Ovando, A.; González-Cortazar, M.; Sosa-Gutiérrez, C.G.; Ojeda-Ramírez, D. Porophyllum Genus Compounds and Pharmacological Activities: A Review. Sci. Pharm. 2021, 89, 7. https://doi.org/10.3390/scipharm89010007

AMA Style

Vázquez-Atanacio MJ, Bautista-Ávila M, Velázquez-González C, Castañeda-Ovando A, González-Cortazar M, Sosa-Gutiérrez CG, Ojeda-Ramírez D. Porophyllum Genus Compounds and Pharmacological Activities: A Review. Scientia Pharmaceutica. 2021; 89(1):7. https://doi.org/10.3390/scipharm89010007

Chicago/Turabian Style

Vázquez-Atanacio, María J.; Bautista-Ávila, Mirandeli; Velázquez-González, Claudia; Castañeda-Ovando, Araceli; González-Cortazar, Manasés; Sosa-Gutiérrez, Carolina G.; Ojeda-Ramírez, Deyanira. 2021. "Porophyllum Genus Compounds and Pharmacological Activities: A Review" Sci. Pharm. 89, no. 1: 7. https://doi.org/10.3390/scipharm89010007

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