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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle
Sci. Pharm. 2016, 84(1), 73-79; (registering DOI)

Criteria for Drug Pricing: Preliminary Experiences with Modeling the Price-Volume Relationship

HTA Unit, Regional Health Service, ESTAR, via San Salvi 12, 50135 Firenze, Italy.
Received: 11 June 2015 / Accepted: 27 August 2015 / Published: 27 August 2015
PDF [169 KB, uploaded 6 September 2016]


In managing drug prices at the national level, price-volume agreements are a tool aimed at ensuring sustainability in cases where the drug price is high and the population is large. These agreements in fact determine a progressive price reduction as more and more patients are treated. Price decays in this context generally have a purely empirical nature, but a theoretical basis would be needed.
The present paper describes a simple model that manages price-volume agreements. Two real examples (ranibizumab for macular degeneration and sofosbuvir for hepatitis C) are analysed in detail. The objective of our analysis was to identify some objective criteria to rationally guide these agreements and to convert these criteria into explicit quantitative rules.
Keywords: Price-volume agreements; Sofosbuvir; Ranibizumab Price-volume agreements; Sofosbuvir; Ranibizumab
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MESSORI, A. Criteria for Drug Pricing: Preliminary Experiences with Modeling the Price-Volume Relationship. Sci. Pharm. 2016, 84, 73-79.

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