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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2016, 84(1), 61-72;

Hyaluronan–Itaconic Acid–Glutaraldehyde Films for Biomedical Applications: Preliminary Studies

PLAPIQUI-CONICET, Universidad Nacional del Sur, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina.
Dpto Biología Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina.
Institute of Applied Ophthalmobiology, University of Valladolid, Paseo de Belén 17, 47011, Valladolid, Spain.
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC), 1900, La Plata, Argentina.
UNITEFA-CONICET, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, X5000HUA, Córdoba, Argentina.
Author to whom correspondence should be addressed.
Received: 27 April 2015 / Accepted: 29 July 2015 / Published: 29 July 2015
PDF [527 KB, uploaded 6 September 2016]


New hyaluronic acid–itaconic acid films were synthesized as potential materials with biomedical applications. In this work, we explored the homogeneous cross-linking reactions of hyaluronic acid using glutaraldehyde in the presence of itaconic acid and triacetin as plasticizers.
Biomechanical properties were assessed in terms of stability by measuring swelling in aqueous environments, investigating wettability using contact angle tests, and evaluating bioadhesive performance. The ductility of the materials was evaluated through stress-strain measurements and the morphology was explored by scanning electron microscopy.
The results show that the incorporation of itaconic acid improved most of the desirable properties, increasing adhesiveness and reducing wettability and swelling. The use of triacetin enhanced the strength, bioadhesiveness, and ductility of the material.
Keywords: Hyaluronan; Cross-link; Polymers; Biomaterials Hyaluronan; Cross-link; Polymers; Biomaterials
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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CALLES, J.A.; RESSIA, J.A.; LLABOT, J.M.; VALLÉS, E.M.; PALMA, S.D. Hyaluronan–Itaconic Acid–Glutaraldehyde Films for Biomedical Applications: Preliminary Studies. Sci. Pharm. 2016, 84, 61-72.

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