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Sci. Pharm.
Volume 84
Issue 1
10.3797/scipharm.1504-17
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Hyaluronan–Itaconic Acid–Glutaraldehyde Films for Biomedical Applications: Preliminary Studies

by
Javier Adrián CALLES
1,2,3,*,
Jorge Aníbal RESSIA
1,4,
Juan Manuel LLABOT
5,
Enrique Marcelo VALLÉS
1 and
Santiago Daniel PALMA
5
1
PLAPIQUI-CONICET, Universidad Nacional del Sur, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina.
2
Dpto Biología Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina.
3
Institute of Applied Ophthalmobiology, University of Valladolid, Paseo de Belén 17, 47011, Valladolid, Spain.
4
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC), 1900, La Plata, Argentina.
5
UNITEFA-CONICET, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, X5000HUA, Córdoba, Argentina.
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2016, 84(1), 61-72; https://doi.org/10.3797/scipharm.1504-17
Submission received: 27 April 2015 / Accepted: 29 July 2015 / Published: 29 July 2015
Versions Notes

Abstract

New hyaluronic acid–itaconic acid films were synthesized as potential materials with biomedical applications. In this work, we explored the homogeneous cross-linking reactions of hyaluronic acid using glutaraldehyde in the presence of itaconic acid and triacetin as plasticizers.
Biomechanical properties were assessed in terms of stability by measuring swelling in aqueous environments, investigating wettability using contact angle tests, and evaluating bioadhesive performance. The ductility of the materials was evaluated through stress-strain measurements and the morphology was explored by scanning electron microscopy.
The results show that the incorporation of itaconic acid improved most of the desirable properties, increasing adhesiveness and reducing wettability and swelling. The use of triacetin enhanced the strength, bioadhesiveness, and ductility of the material.
Keywords: Hyaluronan; Cross-link; Polymers; Biomaterials Hyaluronan; Cross-link; Polymers; Biomaterials

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MDPI and ACS Style

CALLES, J.A.; RESSIA, J.A.; LLABOT, J.M.; VALLÉS, E.M.; PALMA, S.D. Hyaluronan–Itaconic Acid–Glutaraldehyde Films for Biomedical Applications: Preliminary Studies. Sci. Pharm. 2016, 84, 61-72. https://doi.org/10.3797/scipharm.1504-17

AMA Style

CALLES JA, RESSIA JA, LLABOT JM, VALLÉS EM, PALMA SD. Hyaluronan–Itaconic Acid–Glutaraldehyde Films for Biomedical Applications: Preliminary Studies. Scientia Pharmaceutica. 2016; 84(1):61-72. https://doi.org/10.3797/scipharm.1504-17

Chicago/Turabian Style

CALLES, Javier Adrián, Jorge Aníbal RESSIA, Juan Manuel LLABOT, Enrique Marcelo VALLÉS, and Santiago Daniel PALMA. 2016. "Hyaluronan–Itaconic Acid–Glutaraldehyde Films for Biomedical Applications: Preliminary Studies" Scientia Pharmaceutica 84, no. 1: 61-72. https://doi.org/10.3797/scipharm.1504-17

APA Style

CALLES, J. A., RESSIA, J. A., LLABOT, J. M., VALLÉS, E. M., & PALMA, S. D. (2016). Hyaluronan–Itaconic Acid–Glutaraldehyde Films for Biomedical Applications: Preliminary Studies. Scientia Pharmaceutica, 84(1), 61-72. https://doi.org/10.3797/scipharm.1504-17

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