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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2010, 78(3), 423-434;

Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications

Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Postal code: 14155-1339, Iran
Faculty of Nuclear Engineering and Physics, Amir Kabir University, Tehran, Iran
Author to whom correspondence should be addressed.
Received: 26 April 2010 / Accepted: 9 June 2010 / Published: 9 June 2010
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166Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a 166Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 ncm−2s−1) of natural Ho(NO3)3 samples (specific activity = 3–5 GBq/mg), dissolved in acidic media. The radiochemical purity of 166Ho-EDTMP was checked by ITLC (>99%) and stability studies in presence of human serum and final preparation were performed. The biodistribution of 166Ho-EDTMP and 166HoCl3 in wild-type rats was checked by scarification. SPECT imaging of 166Ho-EDTMP was also performed in wild-type rats. A comparative accumulation study for 166Ho-EDTMP and 166HoCl3 was performed for vital organs up to 48h. Significant bone accumulation (>70%) of the tracer in 48h was observed.
Keywords: Holmium-166; EDTMP; Radiopharmaceutical therapy; Biokinetic Holmium-166; EDTMP; Radiopharmaceutical therapy; Biokinetic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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BAHRAMI-SAMANI, A.; BAGHERI, R.; JALILIAN, A.R.; SHIRVANI-ARAni, S.; GHANNADI-MARAGHEH, M.; SHAMSAEE, M. Production, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications. Sci. Pharm. 2010, 78, 423-434.

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