Next Article in Journal
Mouth Dissolving Tablets II: An Overview of Evaluation Techniques
Previous Article in Journal
Viability of the Human Adenocarcinoma Cell Line Caco-2: Influence of Cryoprotectant, Freezing Rate, and Storage Temperature
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessReview
Sci. Pharm. 2009, 77(2), 309-326;

Mouth Dissolving Tablets I: An Overview of Formulation Technology

Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India
Author to whom correspondence should be addressed.
Received: 6 November 2008 / Accepted: 5 March 2009 / Published: 6 March 2009
PDF [202 KB, uploaded 21 December 2016]


Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. MDDDS have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Therefore, these dosage forms have lured the market for a certain section of the patient population which include dysphagic, bed ridden, psychic, geriatric and paediatric patients. Several techniques have been developed in the recent past, to improve the disintegration quality of these delicate dosage forms without affecting their integrity. This article focuses on the technologies available and the advances made so far in the field of fabrication of mouth dissolving tablets. Apart from the conventional methods of fabrication, this review also provides the detailed concept of some unique patented technologies like Zydis, Lyoc, Quicksolv, Orasolv, Durasolv, Flashtab, Oraquick, Wowtab and Ziplet alongwith their advantages and limitations.
Keywords: Mouth dissolving; Fast disintegrating; Dysphagia; Lyophilization; Direct compression Mouth dissolving; Fast disintegrating; Dysphagia; Lyophilization; Direct compression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

SHUKLA, D.; CHAKRABORTY, S.; SINGH, S.; MISHRA, B. Mouth Dissolving Tablets I: An Overview of Formulation Technology. Sci. Pharm. 2009, 77, 309-326.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics



[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top