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Volume 68
Issue 1
10.3797/scipharm.aut-00-10
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Article

Extractional - Spectrophotometric Determination of Fenbendazole and Ornidazole in Pharmaceutical Formulations

by
ALI Z. ABU ZUHRI
1,*,
WOLFGANG VOELTER
2,
SULEIMAN AL-KHALIL
1 and
IMAD SALAHAT
1
1
Chemistry Department, and Medical Tech. Department, An -Najah National University, Nablus, Palestine
2
Abteilung für Physikalische Biochemie des Physiologisch Chemisches Instituts der Universität Tübingen, Hoppe- Selyer Strasse 4, D-72076 Tübingen, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(1), 109-122; https://doi.org/10.3797/scipharm.aut-00-10
Submission received: 31 August 1999 / Revised: 18 November 1999 / Accepted: 18 November 1999 / Published: 3 February 2000
Versions Notes

Abstract

Methods for spectrophotometric determination of fenbendazole and ornidazde are described. The methods are based on the formation and extraction of the ion-pair complex formed between bromothymol blue and either fenbendazole (FBZ) or ornidazole (ORN). The extracted coloured complexes absorb at 416 and 446 nm, respectively. The effect of different factors, e.g. pH, organic solvent, reagent concentration, extraction time, shaking time and common interfering species have been investigated. Fenbendazole and ornidazole can be determined over the range 1.2 to 24.0 ppm and 5.5 to 77.0 ppm, respectively. The precision of the methods was tested for the determination of pure samples of FBZ and ORN and the mean RSD was found to be 3.0 and 2.3% for FBZ and ORN, respectively.The proposed methods were successfully applied for the determination of FBZ and ORN in commercially dosage fornis. A comparison between the suggested methods and the other reported methods was also studied.
Keywords: Spectrophotometric determination; fenbendazole; ornidazole; pharmaceutical formulations Spectrophotometric determination; fenbendazole; ornidazole; pharmaceutical formulations

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MDPI and ACS Style

ZUHRI, A.Z.A.; VOELTER, W.; AL-KHALIL, S.; SALAHAT, I. Extractional - Spectrophotometric Determination of Fenbendazole and Ornidazole in Pharmaceutical Formulations. Sci. Pharm. 2000, 68, 109-122. https://doi.org/10.3797/scipharm.aut-00-10

AMA Style

ZUHRI AZA, VOELTER W, AL-KHALIL S, SALAHAT I. Extractional - Spectrophotometric Determination of Fenbendazole and Ornidazole in Pharmaceutical Formulations. Scientia Pharmaceutica. 2000; 68(1):109-122. https://doi.org/10.3797/scipharm.aut-00-10

Chicago/Turabian Style

ZUHRI, ALI Z. ABU, WOLFGANG VOELTER, SULEIMAN AL-KHALIL, and IMAD SALAHAT. 2000. "Extractional - Spectrophotometric Determination of Fenbendazole and Ornidazole in Pharmaceutical Formulations" Scientia Pharmaceutica 68, no. 1: 109-122. https://doi.org/10.3797/scipharm.aut-00-10

APA Style

ZUHRI, A. Z. A., VOELTER, W., AL-KHALIL, S., & SALAHAT, I. (2000). Extractional - Spectrophotometric Determination of Fenbendazole and Ornidazole in Pharmaceutical Formulations. Scientia Pharmaceutica, 68(1), 109-122. https://doi.org/10.3797/scipharm.aut-00-10

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