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Salmonella Infection in Chronic Inflammation and Gastrointestinal Cancer

Division of Gastroenterology and Hepatology, Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
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Author to whom correspondence should be addressed.
Diseases 2019, 7(1), 28; https://doi.org/10.3390/diseases7010028
Received: 13 January 2019 / Revised: 16 February 2019 / Accepted: 6 March 2019 / Published: 10 March 2019
(This article belongs to the Special Issue Role of Bacterial Infection in Cancer)
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Abstract

Salmonella not only causes acute infections, but can also cause patients to become chronic “asymptomatic” carriers. Salmonella has been verified as a pathogenic factor that contributes to chronic inflammation and carcinogenesis. This review summarizes the acute and chronic Salmonella infection and describes the current research progress of Salmonella infection contributing to inflammatory bowel disease and cancer. Furthermore, this review explores the underlying biological mechanism of the host signaling pathways manipulated by Salmonella effector molecules. Using experimental animal models, researchers have shown that Salmonella infection is related to host biological processes, such as host cell transformation, stem cell maintenance, and changes of the gut microbiota (dysbiosis). Finally, this review discusses the current challenges and future directions in studying Salmonella infection and its association with human diseases. View Full-Text
Keywords: cancer; dysbiosis; inflammation; infection; Salmonella; microbiome; Wnt/β-catenin cancer; dysbiosis; inflammation; infection; Salmonella; microbiome; Wnt/β-catenin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zha, L.; Garrett, S.; Sun, J. Salmonella Infection in Chronic Inflammation and Gastrointestinal Cancer. Diseases 2019, 7, 28.

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