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Gut Microbiome and Cardiovascular Diseases

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Author to whom correspondence should be addressed.
Academic Editor: Luis Vitetta
Diseases 2018, 6(3), 56;
Received: 8 June 2018 / Revised: 27 June 2018 / Accepted: 29 June 2018 / Published: 29 June 2018
(This article belongs to the Special Issue Gut Microbiome and Human Diseases)
PDF [236 KB, uploaded 29 June 2018]


Recent evidence has suggested that the gut microbiome is involved in human health and diseases, such as inflammatory bowel disease, liver cirrhosis, rheumatoid arthritis, and type 2 diabetes. Cardiovascular diseases, which are associated with high morbidity and mortality across the world, are no exception. Increasing evidence has suggested a strong relationship between the gut microbiome and the progression of cardiovascular diseases. We first reported such a relationship with coronary artery disease two years ago. Next-generation sequencing techniques, together with bioinformatics technology, constantly and dramatically expand our knowledge of the complex human gut bacterial ecosystem and reveal the exact role of this bacterial ecosystem in cardiovascular diseases via the functional analysis of the gut microbiome. Such knowledge may pave the way for the development of further diagnostics and therapeutics for prevention and management of cardiovascular diseases. The aim of the current review is to highlight the relationship between the gut microbiome and their metabolites, and the development of cardiovascular diseases by fostering an understanding of recent studies. View Full-Text
Keywords: gut microbiome; cardiovascular diseases; Bacteroides gut microbiome; cardiovascular diseases; Bacteroides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yoshida, N.; Yamashita, T.; Hirata, K.-I. Gut Microbiome and Cardiovascular Diseases. Diseases 2018, 6, 56.

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