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Article

Assessment of Gastrointestinal Adverse Effects during the First Six Months of “Biktarvy” Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period

by
Madalina-Ianca Suba
1,2,
Simona-Alina Abu-Awwad
1,3,*,
Ovidiu Rosca
4,
Mirela-Mădălina Turaiche
5,
Bogdan Hogea
3,6,7,
Ahmed Abu-Awwad
3,6,7,
Razvan Nitu
3,8 and
Voichita Elena Lazureanu
4
1
Doctoral School, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
2
Dr. Victor Babeș Infectious Diseases and Pneumophthisiology Hospital Timisoara, 300310 Timisoara, Romania
3
“Pius Brinzeu” Emergency Clinical County Hospital, Bld Liviu Rebreanu, No. 156, 300723 Timisoara, Romania
4
Department XIII, Discipline of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania
5
Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania
6
Department XV, Discipline of Orthopedics-Traumatology, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
7
Profesor Universitar Doctor Teodor Șora Research Centre, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania
8
Department of Obstetrics and Gynecology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Diseases 2024, 12(1), 3; https://doi.org/10.3390/diseases12010003
Submission received: 10 October 2023 / Revised: 10 December 2023 / Accepted: 19 December 2023 / Published: 21 December 2023
(This article belongs to the Section Infectious Disease)
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Abstract

Background: The battle against HIV has led to the development of antiretroviral therapy (ART), including BIKTARVY®, which combines three potent agents. However, concerns about gastrointestinal side effects during the early phases of treatment have emerged, potentially impacting patient adherence and outcomes. Materials and Methods: This retrospective cohort study, conducted over four years in Romania, examined 222 patients initiated on BIKTARVY® therapy. Data were collected from electronic medical records, and stringent inclusion and exclusion criteria were applied to ensure data accuracy and relevance. Statistical analysis was performed to assess age-related patterns in gastrointestinal symptoms and their relation with significant weight loss. Results: This study revealed significant differences in the prevalence of gastrointestinal symptoms between age groups, with older patients experiencing more symptoms. Notably, diarrhea did not exhibit a statistically significant age-related difference. Furthermore, weight loss exceeding 5 kg was more common in older patients. Of the patients who continued BIKTARVY® therapy, 84.9% showed an increase in CD4 cell counts, and most expressed satisfaction with treatment. Conclusion: Understanding age-related patterns and gastrointestinal side effects of BIKTARVY® is crucial for optimizing HIV patient care. Future research should aim to corroborate and expand upon these findings, potentially leading to improved therapeutic approaches in the ongoing fight against HIV.
Keywords: bictegravir; emtricitabine; tenofovir alafenamide; BIKTARVY®; antiretroviral therapy; HIV; gastrointestinal adverse effects; age-related patterns; weight loss; treatment outcomes bictegravir; emtricitabine; tenofovir alafenamide; BIKTARVY®; antiretroviral therapy; HIV; gastrointestinal adverse effects; age-related patterns; weight loss; treatment outcomes

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MDPI and ACS Style

Suba, M.-I.; Abu-Awwad, S.-A.; Rosca, O.; Turaiche, M.-M.; Hogea, B.; Abu-Awwad, A.; Nitu, R.; Lazureanu, V.E. Assessment of Gastrointestinal Adverse Effects during the First Six Months of “Biktarvy” Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period. Diseases 2024, 12, 3. https://doi.org/10.3390/diseases12010003

AMA Style

Suba M-I, Abu-Awwad S-A, Rosca O, Turaiche M-M, Hogea B, Abu-Awwad A, Nitu R, Lazureanu VE. Assessment of Gastrointestinal Adverse Effects during the First Six Months of “Biktarvy” Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period. Diseases. 2024; 12(1):3. https://doi.org/10.3390/diseases12010003

Chicago/Turabian Style

Suba, Madalina-Ianca, Simona-Alina Abu-Awwad, Ovidiu Rosca, Mirela-Mădălina Turaiche, Bogdan Hogea, Ahmed Abu-Awwad, Razvan Nitu, and Voichita Elena Lazureanu. 2024. "Assessment of Gastrointestinal Adverse Effects during the First Six Months of “Biktarvy” Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period" Diseases 12, no. 1: 3. https://doi.org/10.3390/diseases12010003

APA Style

Suba, M.-I., Abu-Awwad, S.-A., Rosca, O., Turaiche, M.-M., Hogea, B., Abu-Awwad, A., Nitu, R., & Lazureanu, V. E. (2024). Assessment of Gastrointestinal Adverse Effects during the First Six Months of “Biktarvy” Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period. Diseases, 12(1), 3. https://doi.org/10.3390/diseases12010003

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