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Volume 10
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10.3390/diseases10040122
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Article

Gadofosveset-Trinatrium-Enhanced MR Angiography and MR Venography in the Diagnosis of Venous Thromboembolic Disease: A Single-Center Cohort Study

by
Manuela A. Aschauer
1,
Ingeborg M. Keeling
2,*,
Carmen V. Salvan-Schaschl
1,
Igor Knez
2,
Barbara Binder
3,
Reinhard B. Raggam
4 and
Ameli E. Trantina-Yates
2
1
Department of Radiology, Medical University of Graz, 8036 Graz, Austria
2
Department of Cardiac Surgery, Medical University of Graz, 8036 Graz, Austria
3
Department of Dermatology, Medical University of Graz, 8036 Graz, Austria
4
Department of Angiology, Medical University of Graz, 8036 Graz, Austria
*
Author to whom correspondence should be addressed.
Diseases 2022, 10(4), 122; https://doi.org/10.3390/diseases10040122
Submission received: 6 August 2022 / Revised: 19 November 2022 / Accepted: 20 November 2022 / Published: 5 December 2022
(This article belongs to the Section Cardiology)
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Abstract

Background: The aim of this single-center combined prospective/retrospective cohort study was to analyze Gadolinium (Gd)-enhanced MRA (magnetic resonance angiography) and MRV (MR venography) for the diagnosis of pulmonary artery embolism and deep venous thrombosis. The gold standard methods result in major exposure to radiation and a high amount of nephrotoxic iodinated contrast media. This is the first larger contrast-enhanced MR imaging study of acute and chronic venous thromboembolic disease of various stages. Methods: We prospectively examined 88 patients presenting clinical signs of deep vein thrombosis and/or pulmonary artery embolism. A single-session, one-stop shop Gd-enhanced MRA/MRV at 1.5 Tesla, using gradient echo sequences with very short repetition and echo times as well as low flip angles with subtraction and three-dimensional reconstruction, was performed. A diagnosis was made with the consensus of two experienced radiologists. Results: We observed excellent MRA image quality in 87% and even higher diagnostic image quality of MRV in 90% of our examinations. Pulmonary artery embolism occurred with deep vein thrombosis in 22%. Conclusions: Gd-enhanced MRA/MRV provided excellent image quality for the diagnosis of venous thromboembolic disease in the majority of cases. It may be particularly useful to plan and follow-up filter implantation and retrieval in the inferior caval vein.
Keywords: magnetic resonance imaging; magnetic resonance angiography; magnetic resonance venography; gadolinium-containing contrast agent; pulmonary artery embolism; deep vein thrombosis magnetic resonance imaging; magnetic resonance angiography; magnetic resonance venography; gadolinium-containing contrast agent; pulmonary artery embolism; deep vein thrombosis

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MDPI and ACS Style

Aschauer, M.A.; Keeling, I.M.; Salvan-Schaschl, C.V.; Knez, I.; Binder, B.; Raggam, R.B.; Trantina-Yates, A.E. Gadofosveset-Trinatrium-Enhanced MR Angiography and MR Venography in the Diagnosis of Venous Thromboembolic Disease: A Single-Center Cohort Study. Diseases 2022, 10, 122. https://doi.org/10.3390/diseases10040122

AMA Style

Aschauer MA, Keeling IM, Salvan-Schaschl CV, Knez I, Binder B, Raggam RB, Trantina-Yates AE. Gadofosveset-Trinatrium-Enhanced MR Angiography and MR Venography in the Diagnosis of Venous Thromboembolic Disease: A Single-Center Cohort Study. Diseases. 2022; 10(4):122. https://doi.org/10.3390/diseases10040122

Chicago/Turabian Style

Aschauer, Manuela A., Ingeborg M. Keeling, Carmen V. Salvan-Schaschl, Igor Knez, Barbara Binder, Reinhard B. Raggam, and Ameli E. Trantina-Yates. 2022. "Gadofosveset-Trinatrium-Enhanced MR Angiography and MR Venography in the Diagnosis of Venous Thromboembolic Disease: A Single-Center Cohort Study" Diseases 10, no. 4: 122. https://doi.org/10.3390/diseases10040122

APA Style

Aschauer, M. A., Keeling, I. M., Salvan-Schaschl, C. V., Knez, I., Binder, B., Raggam, R. B., & Trantina-Yates, A. E. (2022). Gadofosveset-Trinatrium-Enhanced MR Angiography and MR Venography in the Diagnosis of Venous Thromboembolic Disease: A Single-Center Cohort Study. Diseases, 10(4), 122. https://doi.org/10.3390/diseases10040122

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