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Article

A Web-Based Tool for Automatic Detection and Visualization of DNA Differentially Methylated Regions

Departamento de Informática, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
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Author to whom correspondence should be addressed.
Academic Editor: David Defour
Electronics 2021, 10(9), 1083; https://doi.org/10.3390/electronics10091083
Received: 8 April 2021 / Revised: 23 April 2021 / Accepted: 26 April 2021 / Published: 3 May 2021
(This article belongs to the Special Issue High-Performance Computer Architectures and Applications)
The study of Deoxyribonucleic Acid (DNA) methylation has allowed important advances in the understanding of genetic diseases related to abnormal cell behavior. DNA methylation analysis tools have become especially relevant in recent years. However, these tools have a high computational cost and some of them require the configuration of specific hardware and software, extending the time for research and diagnosis. In previous works, we proposed some tools for DNA methylation analysis and a new tool, called HPG-DHunter, for the detection and visualization of Differentially Methylated Regions (DMRs). Even though this tool offers a user-friendly interface, its installation and maintenance requires the information technology knowledge specified above. In this paper, we propose our tool as a web-based application, which allows biomedical researchers the use of a powerful tool for methylation analysis, even for those not specialized in the management of Graphics Processing Units (GPUs) and their related software. The performance evaluation results show that this web-based version of HPG-DHunter tool improves the response time offered to the user, also offering an improved interface and higher visualization quality, while showing the same efficiency in DMR identification than the standalone version. View Full-Text
Keywords: DNA methylation; wavelet transform; GPU computing; web-based application DNA methylation; wavelet transform; GPU computing; web-based application
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MDPI and ACS Style

Fernández, L.; Olanda, R.; Pérez, M.; Orduña, J.M. A Web-Based Tool for Automatic Detection and Visualization of DNA Differentially Methylated Regions. Electronics 2021, 10, 1083. https://doi.org/10.3390/electronics10091083

AMA Style

Fernández L, Olanda R, Pérez M, Orduña JM. A Web-Based Tool for Automatic Detection and Visualization of DNA Differentially Methylated Regions. Electronics. 2021; 10(9):1083. https://doi.org/10.3390/electronics10091083

Chicago/Turabian Style

Fernández, Lisardo, Ricardo Olanda, Mariano Pérez, and Juan M. Orduña 2021. "A Web-Based Tool for Automatic Detection and Visualization of DNA Differentially Methylated Regions" Electronics 10, no. 9: 1083. https://doi.org/10.3390/electronics10091083

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