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Antioxidant and Anti-Aging Potential of Indian Sandalwood Oil against Environmental Stressors In Vitro and Ex Vivo

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Centre International de Développement Pharmaceutique (CIDP), BioPark, Socota Phoenicia, Sayed Hossen Road, Phoenix 73408, Mauritius
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Quintis Pty Ltd., Level 1, 87 Colin Street, West Perth 6005, Australia
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Clipeum Pharma, 06530 Peymeinade, France
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Authors to whom correspondence should be addressed.
Academic Editor: Ron Kohen
Cosmetics 2021, 8(2), 53; https://doi.org/10.3390/cosmetics8020053
Received: 21 May 2021 / Revised: 9 June 2021 / Accepted: 14 June 2021 / Published: 19 June 2021
Distilled from the heartwood of Santalum album, Indian sandalwood oil is an essential oil that historically has been used as a natural active ingredient in cosmetics to condition and brighten the skin. It has been documented to exhibit antioxidant, anti-inflammatory, and anti-proliferative activities. Here, we investigated the protective and anti-aging effects of Indian sandalwood oil in scavenging reactive oxygen species (ROS) in HaCaT cells and in human skin explants after exposure to oxidative stress. Using a probe DCFH-DA, the antioxidant capacity of Indian sandalwood oil was monitored following exposure to blue light at 412 nm and 450 nm or cigarette smoke. The anti-aging effect of sandalwood oil was also explored in human skin explants via the assessment of collagenase level (MMP-1). We reported that Indian sandalwood oil possessed antioxidant potential that can scavenge the ROS generated by a free radical generating compound (AAPH). Subsequent exposure to environmental stressors revealed that Indian sandalwood oil possessed superior antioxidant activity in comparison to vitamin E (alpha tocopherol). Using human skin explants, this study demonstrated that Indian sandalwood oil can also inhibit the pollutant-induced level of MMP-1. The findings indicated that Indian sandalwood oil can potentially serve as a protective and anti-aging active ingredient in cosmetics and dermatology against environmental stressors. View Full-Text
Keywords: exposomes; ex vivo; in vitro; oxidative stress; aging; Indian sandalwood oil exposomes; ex vivo; in vitro; oxidative stress; aging; Indian sandalwood oil
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MDPI and ACS Style

Francois-Newton, V.; Brown, A.; Andres, P.; Mandary, M.B.; Weyers, C.; Latouche-Veerapen, M.; Hettiarachchi, D. Antioxidant and Anti-Aging Potential of Indian Sandalwood Oil against Environmental Stressors In Vitro and Ex Vivo. Cosmetics 2021, 8, 53. https://doi.org/10.3390/cosmetics8020053

AMA Style

Francois-Newton V, Brown A, Andres P, Mandary MB, Weyers C, Latouche-Veerapen M, Hettiarachchi D. Antioxidant and Anti-Aging Potential of Indian Sandalwood Oil against Environmental Stressors In Vitro and Ex Vivo. Cosmetics. 2021; 8(2):53. https://doi.org/10.3390/cosmetics8020053

Chicago/Turabian Style

Francois-Newton, Véronique, Andrew Brown, Philippe Andres, Madiiha B. Mandary, Carli Weyers, Mélissa Latouche-Veerapen, and Dhanushka Hettiarachchi. 2021. "Antioxidant and Anti-Aging Potential of Indian Sandalwood Oil against Environmental Stressors In Vitro and Ex Vivo" Cosmetics 8, no. 2: 53. https://doi.org/10.3390/cosmetics8020053

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