Next Article in Journal
Bioglea as a Source of Bioactive Ingredients: Chemical and Biological Evaluation
Previous Article in Journal
A New Benchmark to Determine What Healthy Western Skin Looks Like in Terms of Biodiversity Using Standardised Methodology
Article

Retinol Has a Skin Dehydrating Effect That Can Be Improved by a Mixture of Water-Soluble Polysaccharides

1
BotanicalsPlus®, Fairfield, NJ 07004, USA
2
Jeen® International, Fairfield, NJ 07004, USA
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(4), 80; https://doi.org/10.3390/cosmetics7040080
Received: 22 September 2020 / Revised: 13 October 2020 / Accepted: 23 October 2020 / Published: 27 October 2020
It is common that retinoids used in skincare can cause skin dryness, irritation and redness which is a complaint for the use of these molecules in skincare formulations. Objective: to investigate the influence of a mixture of polysaccharides to improve retinol-based formulations in a 12-day inner volar forearm study. Methods: in total, 22 inner volar forearms were treated over a 12-day topical application of a Placebo formulation containing 0.5% retinol verses a formulation containing 0.5% retinol and 3.0% of a complex of polysaccharides. Application occurred 2X/day in the morning and evening. Skin testing included barrier disruption, erythema, and skin hydration. After a 3-day regression of treatment, skin hydration was measured again. Results: the 0.5% retinol Placebo formulation showed a significant impact on skin dehydration compared to untreated control or polysaccharide-treated areas. The formulation containing retinol and 3.0% of the polysaccharides, maintained skin hydration levels comparable to the untreated control. Neither formulation had a statistically significant impact on skin erythema or barrier disruption. After the 3-day regression, the polysaccharide mixture continued to demonstrate significant moisturization benefits superior to the untreated and active-treated sites. Conclusions: a mixture of polysaccharides was able to mitigate the short-term skin drying effects of retinol and continued to moisturize the skin after a 3-Day regression. View Full-Text
Keywords: retinol; dryness; polysaccharides; erythema; barrier disruption; hydration retinol; dryness; polysaccharides; erythema; barrier disruption; hydration
Show Figures

Graphical abstract

MDPI and ACS Style

Gruber, J.V.; Stojkoska, V.; Riemer, J. Retinol Has a Skin Dehydrating Effect That Can Be Improved by a Mixture of Water-Soluble Polysaccharides. Cosmetics 2020, 7, 80. https://doi.org/10.3390/cosmetics7040080

AMA Style

Gruber JV, Stojkoska V, Riemer J. Retinol Has a Skin Dehydrating Effect That Can Be Improved by a Mixture of Water-Soluble Polysaccharides. Cosmetics. 2020; 7(4):80. https://doi.org/10.3390/cosmetics7040080

Chicago/Turabian Style

Gruber, James V., Venera Stojkoska, and Jed Riemer. 2020. "Retinol Has a Skin Dehydrating Effect That Can Be Improved by a Mixture of Water-Soluble Polysaccharides" Cosmetics 7, no. 4: 80. https://doi.org/10.3390/cosmetics7040080

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop