A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from Pterocarpus Marsupium
by
Muhammed Majeed 1,2,3,4, Shaheen Majeed 1,2,3,4
, Renuka Jain 1,4,*, Lakshmi Mundkur 1, H. R. Rajalakshmi 4, Prachi Lad 4 and Prakriti Neupane 4
Muhammed Majeed 1,2,3,4, Shaheen Majeed 1,2,3,4, Renuka Jain 1,4,*, Lakshmi Mundkur 1, H. R. Rajalakshmi 4, Prachi Lad 4 and Prakriti Neupane 4
1
Sami Labs Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bangalore, Karnataka 560058, India
2
Sabinsa Corporation, 20 Lake Dr, East Windsor, NJ 08520, USA
3
Sabinsa Corporation, 750 Innovation Cir, Payson, UT 84651, USA
4
ClinWorld Private Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bengaluru, Karnataka 560058, India
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(1), 16; https://doi.org/10.3390/cosmetics7010016
Received: 11 January 2020 / Revised: 17 February 2020 / Accepted: 19 February 2020 / Published: 10 March 2020
Ultraviolet (UV) rays and its harmful effects have always been a concern to skin health. Sunscreen and sunblock prevent the harmful effects of UV radiation on the skin. Sun Protection Factor (SPF) is an indication of the sun-protective capacity of an ingredient. There is an ever increasing interest in the cosmetic industry for developing novel functional ingredients from natural sources. The purpose of this study was to determine in-vitro and in vivo SPF of natural 90% pterostilbene extracted from the dried heartwood of Pterocarpus marsupium (Indian Kino). The SPF of purified pterostilbene and a formulation containing 0.4% pterostilbene was determined In Vitro using a UV spectrophotometer. Pterostilbene had an SPF of 21.73 ± 0.06, while the cream formulation had an SPF of 8.84 ± 0.01. The in vivo SPF of the 0.4% pterostilbene cream in humans was found to be 6.2 ± 1.30. Primary skin irritation tests in human subjects showed the formulation was safe and had no irritation potential. Pterostilbene was also found to have significant antioxidant activity as determined by free radical scavenging assays in vitro. These results suggest that natural pterostilbene is an antioxidant and shows SPF value both in-vitro and in the human clinical study and thus could be used as an ingredient in topical sun-protective formulations.
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Keywords:
Pterostilbene; PteroWhite®; sun protection factor; SPF; sunscreen application; sun UV protection; in vitro; in vivo; ISO 24444 method; minimal erythema dose
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Majeed, M.; Majeed, S.; Jain, R.; Mundkur, L.; Rajalakshmi, H.R.; Lad, P.; Neupane, P. A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from Pterocarpus Marsupium. Cosmetics 2020, 7, 16.
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