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Contact Allergy to Fragrances: In Vitro Opportunities for Safety Assessment

Laboratory of Toxicology, Department of Environmental Science and Policy, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
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Cosmetics 2019, 6(1), 3; https://doi.org/10.3390/cosmetics6010003
Received: 27 November 2018 / Revised: 26 December 2018 / Accepted: 30 December 2018 / Published: 4 January 2019
(This article belongs to the Special Issue Contact Allergy to Fragrances)
The majority of cosmetic products contain fragrances to make products more pleasant to the consumer, as we all like goods that smell nice. Unfortunately, contact allergy to fragrance compounds is among the most frequent findings in patients with suspected allergic contact dermatitis. In order to revert this and to reduce contact allergy to cosmetics, it is imperative to improve safety assessment of cosmetic products for skin sensitization. In the era of animal ban for cosmetic ingredients, this represents a challenge. Luckily, in the last decades, substantial progress has been made in the understanding of the mechanism of chemical-induced contact allergy and several in vitro methods are available for hazard identification. The purpose of this manuscript is to explore the possibility of non-animal testing for quantitative risk assessment of fragrance-induced contact allergy, essential for cosmetic products, which cannot be tested on animals. View Full-Text
Keywords: skin sensitization; fragrances; non-animal test; NESIL; hazard identification; quantitative risk assessment skin sensitization; fragrances; non-animal test; NESIL; hazard identification; quantitative risk assessment
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Corsini, E.; Galbiati, V. Contact Allergy to Fragrances: In Vitro Opportunities for Safety Assessment. Cosmetics 2019, 6, 3.

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