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Article

Schisandra chinensis Protects the Skin from Global Pollution by Inflammatory and Redox Balance Pathway Modulations: An In Vitro Study

1
Greentech, Biopôle Clermont-Limagne, 63360 Saint Beauzire, France
2
Syntivia, Place Pierre Potier, 31106 Toulouse CEDEX 1, France
3
Complexity, Innovation, and Sport Activity department (CIAMS), University of Paris-Saclay, 91405 Orsay CEDEX, France
4
CIAMS department, University of Orléans, 45067 Orléans, France
*
Author to whom correspondence should be addressed.
Cosmetics 2018, 5(2), 36; https://doi.org/10.3390/cosmetics5020036
Received: 3 April 2018 / Revised: 17 May 2018 / Accepted: 4 June 2018 / Published: 7 June 2018
Epidemiological results show that airborne particulate matter (PM) induces health alterations in line with pulmonary and cardiovascular pathologies. Deleterious effects of PM on the skin have also been investigated. A possible approach to prevent Reactive Oxygen Species (ROS)-mediated disorders for both preventive and treatment means is based on the use of substances, which can be found in plants. These can act as secondary metabolites, and lignans are a promising candidate. Thus, the objective of this study was firstly to identify reconstructed human epidermis, using a transcriptomic approach, and also to identify the effects of Urban Dust and of Urban Dust and Schisandra chinensis (S.C.) extract on the expression of genes that are involved in the response to cellular protection mechanisms. Secondly, we examined the effect of an active extract from S.C. on the protection of human keratinocytes damages that were caused by pollution, through the evaluation of Nrf2 and AhR pathways, NF-kB, and DJ-1. Urban Dust included the over-expression of metalloproteinases MMP-1 and MMP-9 and an increase in Glutathione peroxidase 2 (GPX2). In the presence of Urban Dust, S.C. extract activated the over-expression of several genes that are involved in the antioxidant response and in the detoxification pathway, including Ferritin light chain (FTL) and GPX2. Exposure to urban dust activated the cytoplasmic expression of NF-kB and AhR, when compared to the control. Co-treatment of Urban Dust and S.C. extract increased DJ-1 protein levels, Nrf2 expression, and decreased AhR and NF-kB in the cytoplasm. At the same time, this co-treatment increased SOD2 expression (50%: p < 0.001) and catalase activity (120%: p < 0.05), when compared to Urban Dust alone. Thus, S.C. might be able to protect the Normal Human Epidermal Keratinocytes (NHEK) from environmental aggression, by fighting the harmful effects of urban pollution. View Full-Text
Keywords: pollution; oxidative stress; Schisandra chinensis; Nrf2; DJ-1 pollution; oxidative stress; Schisandra chinensis; Nrf2; DJ-1
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MDPI and ACS Style

Ranouille, E.; Boutot, C.; Bony, E.; Bombarde, O.; Grosjean, S.; Lazewski, A.; Berthon, J.-Y.; Filaire, E. Schisandra chinensis Protects the Skin from Global Pollution by Inflammatory and Redox Balance Pathway Modulations: An In Vitro Study. Cosmetics 2018, 5, 36. https://doi.org/10.3390/cosmetics5020036

AMA Style

Ranouille E, Boutot C, Bony E, Bombarde O, Grosjean S, Lazewski A, Berthon J-Y, Filaire E. Schisandra chinensis Protects the Skin from Global Pollution by Inflammatory and Redox Balance Pathway Modulations: An In Vitro Study. Cosmetics. 2018; 5(2):36. https://doi.org/10.3390/cosmetics5020036

Chicago/Turabian Style

Ranouille, Edwige, Carine Boutot, Emilie Bony, Oriane Bombarde, Sarah Grosjean, Antoine Lazewski, Jean-Yves Berthon, and Edith Filaire. 2018. "Schisandra chinensis Protects the Skin from Global Pollution by Inflammatory and Redox Balance Pathway Modulations: An In Vitro Study" Cosmetics 5, no. 2: 36. https://doi.org/10.3390/cosmetics5020036

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