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Cosmetics 2018, 5(2), 29;

Skin Regenerative and Anti-Cancer Actions of Copper Peptides

Skin Biology, 4122 Factoria Boulevard SE, Suite Number 200, Bellevue, WA 98006, USA
Author to whom correspondence should be addressed.
Received: 26 March 2018 / Revised: 14 April 2018 / Accepted: 17 April 2018 / Published: 21 April 2018
(This article belongs to the Special Issue Skin Cancer)
PDF [232 KB, uploaded 3 May 2018]


Topical remedies capable of protecting skin from damage and supporting its regeneration can improve skin’s health as well as its appearance. Small copper peptides have an excellent safety record and are widely used in cosmetic products. The most studied copper peptide is GHK-Cu (glycyl-L-histidyl-L-lysine), a small copper-binding peptide, naturally present in human plasma. Since its discovery in 1973, in vivo and in vitro studies have shown that GHK-Cu possesses a wealth of health-positive actions including improving wound contraction and epithelization, and increasing the production of growth factors and activity of antioxidant enzymes. Recently, gene expression profiling shed new light on diverse biological actions of GHK-Cu. The present paper discusses evidence of GHK-Cu and other small copper peptides possessing potent anti-cancer properties. View Full-Text
Keywords: GHK-Cu; copper peptides; skin cancer; gene profiling; gene expression; regeneration GHK-Cu; copper peptides; skin cancer; gene profiling; gene expression; regeneration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pickart, L.; Margolina, A. Skin Regenerative and Anti-Cancer Actions of Copper Peptides. Cosmetics 2018, 5, 29.

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