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Open AccessFeature PaperArticle

Polyamide Microparticles Containing Vitamin C by Interfacial Polymerization: An Approach by Design of Experimentation

by Lionel Ripoll 1,* and Yohann Clement 2,*
1
Département des Sciences Fondamentales, Université du Québec à Chicoutimi, 555 Boulevard de l’Université, Saguenay, QC G7H 2B1, Canada
2
Institut des Sciences Analytiques, Université Claude Bernard, Lyon 1, 5 Rue de la Doua, Villeurbanne 69100, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Cosmetics 2016, 3(4), 38; https://doi.org/10.3390/cosmetics3040038
Received: 21 September 2016 / Revised: 19 October 2016 / Accepted: 20 October 2016 / Published: 2 November 2016
Vitamin C is widely use in cosmetics and pharmaceutics products for its active properties. However ascorbic acid shows unfavourable chemical instability such as oxidation leading to formulation problems. Therefore, carriers, such as micro- and nanoparticles, have been widely investigated as delivery systems for vitamin C to improve its beneficial effects in skin treatment. However, none of the previous studies have been able to produce microparticles with a high encapsulation entrapment of vitamin C. The aim of the present study is to use an experimental design to optimize the synthesis of polyamide microparticles for the delivery of ascorbic acid. The effect of four formulation parameters on microparticles properties (size and morphology, encapsulation efficiency and yield, release kinetics) were investigated using a surface response design. Finally, we were able to obtain stable microparticles containing more than 65% of vitamin C. This result confirms the effectiveness of using design of experiments for the optimisation of microparticle formulation and supports the proposal of using them as candidate for the delivery of vitamin C in skin treatment. View Full-Text
Keywords: microparticles; design of experiments; vitamin C; polymerization; antioxidants microparticles; design of experiments; vitamin C; polymerization; antioxidants
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Ripoll, L.; Clement, Y. Polyamide Microparticles Containing Vitamin C by Interfacial Polymerization: An Approach by Design of Experimentation. Cosmetics 2016, 3, 38.

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