Next Article in Journal
Skin Whitening Cosmetics: Feedback and Challenges in the Development of Natural Skin Lighteners
Previous Article in Journal
Essential of Hair Care Cosmetics
Article

Topical Retinol Restores Type I Collagen Production in Photoaged Forearm Skin within Four Weeks

Department of Dermatology, University of Michigan, R6447 Med Sci I, 1150 W Medical Center Drive, Ann Arbor, MI 48109-5609, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Cosmetics 2016, 3(4), 35; https://doi.org/10.3390/cosmetics3040035
Received: 26 August 2016 / Revised: 16 September 2016 / Accepted: 26 September 2016 / Published: 29 September 2016
Production of type I collagen (COL1), the major structural protein of the skin, declines during aging, leading to skin thinning and becoming fragile, which increases the risk of bruising and wound healing disorders in the elderly. Topical treatments that can restore COL1 synthesis and ultimately COL1 content in aged skin hold promise to improve skin health. Much effort has been spent on developing agents that can safely and effectively enhance COL1 synthesis in aged skin. However, how fast and to what extent COL1 production in aged skin can be enhanced by a topical treatment remains unclear. Herein, we investigated a four-week topical retinol (ROL) treatment. A one-day occlusion of ROL (0.4%) or vehicle was applied on photoaged forearms of elderly (>65 years old) subjects once a week for four weeks. Vehicle was also applied on forearms of young (23–33 years) subjects in the same manner. Skin samples were obtained one week after the last treatment and analyzed for COL1 synthesis. We found that the ROL treatment increased the level of COL1 mRNA (2.3-fold) and proCOL1 protein (1.8-fold) in photoaged forearms to levels similar to that of young forearms within four weeks. Our study proves the concept that reduced COL1 production in aged skin can be readily restored. In addition, our study provides an evidence-based foundation for developing COL1-enhancing topical agents, and establishes a reliable and practical efficacy test for evaluating such agents. View Full-Text
Keywords: retinol; type I collagen; skin aging retinol; type I collagen; skin aging
Show Figures

Figure 1

MDPI and ACS Style

Sun, M.; Wang, P.; Sachs, D.; Xu, Y.; Xu, Y.; Voorhees, J.J.; Fisher, G.J.; Li, Y. Topical Retinol Restores Type I Collagen Production in Photoaged Forearm Skin within Four Weeks. Cosmetics 2016, 3, 35. https://doi.org/10.3390/cosmetics3040035

AMA Style

Sun M, Wang P, Sachs D, Xu Y, Xu Y, Voorhees JJ, Fisher GJ, Li Y. Topical Retinol Restores Type I Collagen Production in Photoaged Forearm Skin within Four Weeks. Cosmetics. 2016; 3(4):35. https://doi.org/10.3390/cosmetics3040035

Chicago/Turabian Style

Sun, Min, Peiru Wang, Dana Sachs, Yang Xu, Yiru Xu, John J. Voorhees, Gary J. Fisher, and Yong Li. 2016. "Topical Retinol Restores Type I Collagen Production in Photoaged Forearm Skin within Four Weeks" Cosmetics 3, no. 4: 35. https://doi.org/10.3390/cosmetics3040035

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop