Oxidative Stress and Human Skin Connective Tissue Aging
AbstractEveryone desires healthy and beautiful-looking skin. However, as we age, our skin becomes old due to physiological changes. Reactive oxygen species (ROS) is an important pathogenic factor involved in human aging. Human skin is exposed to ROS generated from both extrinsic sources such as as ultraviolet (UV) light from the sun, and intrinsic sources such as endogenous oxidative metabolism. ROS-mediated oxidative stress damages the collagen-rich extracellular matrix (ECM), the hallmark of skin connective tissue aging. Damage to dermal collagenous ECM weakens the skin’s structural integrity and creates an aberrant tissue microenvironment that promotes age-related skin disorders, such as impaired wound healing and skin cancer development. Here, we review recent advances in our understanding of ROS/oxidative stress and skin connective tissue aging. View Full-Text
Share & Cite This Article
Tu, Y.; Quan, T. Oxidative Stress and Human Skin Connective Tissue Aging. Cosmetics 2016, 3, 28.
Tu Y, Quan T. Oxidative Stress and Human Skin Connective Tissue Aging. Cosmetics. 2016; 3(3):28.Chicago/Turabian Style
Tu, Yidong; Quan, Taihao. 2016. "Oxidative Stress and Human Skin Connective Tissue Aging." Cosmetics 3, no. 3: 28.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.