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Cosmetics 2016, 3(3), 28;

Oxidative Stress and Human Skin Connective Tissue Aging

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Received: 14 June 2016 / Revised: 1 August 2016 / Accepted: 2 August 2016 / Published: 5 August 2016
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Everyone desires healthy and beautiful-looking skin. However, as we age, our skin becomes old due to physiological changes. Reactive oxygen species (ROS) is an important pathogenic factor involved in human aging. Human skin is exposed to ROS generated from both extrinsic sources such as as ultraviolet (UV) light from the sun, and intrinsic sources such as endogenous oxidative metabolism. ROS-mediated oxidative stress damages the collagen-rich extracellular matrix (ECM), the hallmark of skin connective tissue aging. Damage to dermal collagenous ECM weakens the skin’s structural integrity and creates an aberrant tissue microenvironment that promotes age-related skin disorders, such as impaired wound healing and skin cancer development. Here, we review recent advances in our understanding of ROS/oxidative stress and skin connective tissue aging. View Full-Text
Keywords: ROS; oxidative stress; MMPs; TGF-β; CCN1; skin aging; fibroblasts; ECM; collagen ROS; oxidative stress; MMPs; TGF-β; CCN1; skin aging; fibroblasts; ECM; collagen

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Tu, Y.; Quan, T. Oxidative Stress and Human Skin Connective Tissue Aging. Cosmetics 2016, 3, 28.

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