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Review

Anti-Melanogenesis Effect of Quercetin

by 1 and 1,2,*
1
Major in Cosmetic Engineering, Department of Chemical Engineering, Graduate School of Chosun University, Pilmundaero, Dong-gu, Gwangju 501-759, Korea
2
Department of Biochemical and Polymer Engineering, Chosun University, Pilmundaero, Dong-gu, Gwangju 501-759, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Johanna Maria Gillbro
Cosmetics 2016, 3(2), 18; https://doi.org/10.3390/cosmetics3020018
Received: 20 February 2016 / Revised: 13 April 2016 / Accepted: 2 May 2016 / Published: 11 May 2016
Whitening cosmetics with anti-melanogenesis activity are very popular worldwide. Many companies have tried to identify novel ingredients that show anti-melanogenesis effects for new product development. Among many plant-derived compounds, polyphenols are thought to be one of the most promising anti-melanogenesis ingredients. In order to prepare effective whitening polyphenols, 3,3,4,5,7-pentahydrosyflavone (quercetin) has been widely researched and applied to commercial products because it is present in high levels in many edible plants. Quercetin is thus a representative polyphenol and has recently gained attention in the cosmetics field. There are many controversies, however, regarding the effect of quercetin, based on in vitro studies, cell line experiments, and human trials. In this review, toxicity and efficacy data for quercetin and its derivatives in various experimental conditions (i.e., various cell lines, concentration ranges, and other parameters) were examined. Based on this analysis, quercetin itself is shown to be ineffective for hypopigmentation of human skin. However, a few types of quercetin derivatives (such as glycosides) show some activity in a concentration-dependent manner. This review provides clarity in the debate regarding the effects of quercetin. View Full-Text
Keywords: anti-melanogenesis; polyphenol; whitening cosmetics; hyperpigmentation; tyrosinase; quercetin anti-melanogenesis; polyphenol; whitening cosmetics; hyperpigmentation; tyrosinase; quercetin
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MDPI and ACS Style

Choi, M.-H.; Shin, H.-J. Anti-Melanogenesis Effect of Quercetin. Cosmetics 2016, 3, 18. https://doi.org/10.3390/cosmetics3020018

AMA Style

Choi M-H, Shin H-J. Anti-Melanogenesis Effect of Quercetin. Cosmetics. 2016; 3(2):18. https://doi.org/10.3390/cosmetics3020018

Chicago/Turabian Style

Choi, Moon-Hee, and Hyun-Jae Shin. 2016. "Anti-Melanogenesis Effect of Quercetin" Cosmetics 3, no. 2: 18. https://doi.org/10.3390/cosmetics3020018

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