Disturbances in the Skin Homeostasis: Wound Healing, an Undefined Process

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This work is about the Disturbances in the skin homeostasis, particularly the wound healing. This is an important matter and completely in the scope of the journal.

Overall, it is a significant document on this matter. However, in order to be published, in my opinion, there are some major and minor changes to be addressed:

 

Major changes:

1)     Page 1: independently of being a review, there should be a small introduction to contextualize and reference what will be discussed.

2)     Page 2, Figure 1: In the Figure there should be some information indicating the localization of epidermis and the dermis.

3)     The authors should divide the headings and subheadings with numbers and according to the journal's format. This comment applies to the entire document. Often, it's not easy to understand the organization of the divisions.

4)     Page 3, Line 73-97: Please include references.

5)     Page 3-10, Line 98-409: References are always 1-12. In my opinion it would be better to be more specific.

6)     Page 8; Line 273-321: The ref is (1-12) in the end. Along the text it would be useful to have specific references.

7)     Page 11, Line 437: Again it would be very useful to have headings and subheadings organized.

8)     Page 16, Line 619: A reference is needed supporting this information.

9)     Pag2 16, Line 622: A reference is needed supporting this information.

10) Pag2 17: The headings must be organized; Gross stages of wound healing, Acute inflammatory reaction and Summary of principal events in wound healing? Please try to reorganize them.

 

Minor changes:

 

1)            Page 17, Line 668: Why gross?

2)            Page 22, Table 1: Please format it according to journal guidelines.

3)            Page 23. Table 1: The reference at line 808 is what? Based on? Adapted from?

 

 

Overall this is an elegant manuscript summarizing important issues concerning wound healing that after these changes can be considered for publication.

Author Response

The authors would like to thank Reviewer n.1  for her/his comment. To facilitate understanding of the text, a table has been added regarding the meaning of the acronyms used in the text. Every change is highlighted.

Comments and Suggestions for Authors

This work is about the Disturbances in the skin homeostasis, particularly the wound healing. This is an important matter and completely in the scope of the journal.

Overall, it is a significant document on this matter. However, in order to be published, in my opinion, there are some major and minor changes to be addressed:

Major changes:

Q1)   Page 1: independently of being a review, there should be a small introduction to contextualize and reference what will be discussed.

A1)   We have now added an introductory paragraph dedicated to the objectives that the manuscript intends to set (see page 1, lines 62-80).

Q2)   Page 2, Figure 1: In the Figure there should be some information indicating the localization of epidermis and the dermis.

A2)   We have now added the informations suggested in Fig. 1 (see page 2, line 93).

Q3)  The authors should divide the headings and subheadings with numbers and according to the journal's format. This comment applies to the entire document. Often, it's not easy to understand the organization of the divisions.

A3)   We have now divided the headings and subheadings with numbers and according to the journal's format (please visit the whole document).

Q4)   Page 3, Line 73-97: Please include references.

A4)  We have now added the appropriate refs (see pages 3-4, lines 136-168 of the new revised version).

Q5)    Page 3-10, Line 98-409: References are always 1-12. In my opinion it would be better to be more specific.

A5)    We have now added the appropriate refs (see pages 4-11, lines 169-500 of the new revised version).

Q6)   Page 8; Line 273-321: The ref is (1-12) in the end. Along the text it would be useful to have specific references.

A6)   We have now added the appropriate refs (see pages 8-9, lines 353-421 of the new revised version).

Q7)    Page 11, Line 437: Again it would be very useful to have headings and subheadings organized.

A7)  We have now divided the headings and subheadings with numbers and according to the journal's format (please visit the whole document).

Q8)   Page 16, Line 619: A reference is needed supporting this information.

A8)  We have now added the appropriate refs (see page 16, lines 761-778 of the new revised version).

Q9)  Pag 2 16, Line 622: A reference is needed supporting this information.

A9) We have now added the appropriate refs (see page 16, lines 761-778 of the new revised version).

10)   Pag 2 17: The headings must be organized; Gross stages of wound healing, Acute inflammatory reaction and Summary of principal events in wound healing? Please try to reorganize them.            

10)   We have now divided the headings and subheadings with numbers and according to the journal's format (please visit the whole document).

Minor changes:

Q1)         Page 17, Line 668: Why gross?

A1)         We have now changed the title of the paragraph (see page 17, line 797 of the new revised version).

Q2)        Page 22, Table 1: Please format it according to journal guidelines.

A2)         We have formatted the table 1 in according to journal guidelines (see page 22, line 1006 of the new revised version).

Q3)        Page 23, Table 1: The reference at line 808 is what? Based on? Adapted from?

A3)         We have now used the term modified see page 22, line 1009 of the new revised version).

 Comment of Ref.1

C1) Overall this is an elegant manuscript summarizing important issues concerning wound healing that after these changes can be considered for publication.

A1) The authors express their heartfelt thanks

 

Reviewer 2 Report

Comments and Suggestions for Authors

Comments to the authors:

1. The figures were taken from other publications should be provided the permission.

2. In table 1 proliferation sections should be merged n one section as well as maturation section. 

3. Wound dressing should be provided as a section. 

Comments on the Quality of English Language

Moderate editing of English language required.

Author Response

The authors would like to thank Reviewer n.2  for her/his comment. To facilitate understanding of the text, a table has been added regarding the meaning of the acronyms used in the text. Every change is highlighted.

Comments and Suggestions for Authors

Comments to the authors:

Q1) The figures were taken from other publications should be provided the permission.

A1) The authors apologize for the misunderstanding. The term courtesy was used inappropriately. The colleagues mentioned in the legends have been placed in the acknowledgments section. After careful inspection the pictures proposed do not come from published manuscripts

Q2). In table 1 proliferation sections should be merged n one section as well as maturation section. 
A2)  Proliferation and maturations sections of table 1 are now merged (see page 22, line 1006).

Q3)  Wound dressing should be provided as a section.
A3) The section about wound dressing is now added (see page 26-27, lines 1272-1421).

Comments on the Quality of English Language

Moderate editing of English language required.

 

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The manuscript has significantly improved.

It is publishable in present form.

Reviewer 2 Report

Comments and Suggestions for Authors

The most concerns have been carefully addressed.