The aim of this editorial is to briefly introduce some papers of different nature presented by the contributors to the special issue on “Second Generation General System Theory”. These contributions have been focused on the need for building a post-Bertalanffy
Systemics, based on new problems, representations, and approaches to complexity. Furthermore, such new Systemics is expected to be able to theoretically generalize
new related systemic concepts and approaches introduced by different disciplines. Such a theoretical generalization is going to coincide with a new kind of interdisciplinarity. The latter should substitute the classical one, based on considering problems and solutions within a discipline as equivalent to problems and solutions within another one. This equivalence was used within the framework of general systemic concepts like Anticipation, Completeness, Feedback, Finality, Forecast, Separability, Openness, and Reversibility. The contributions contained in this special issue constitute very interesting examples of new approaches and of their possibilities of theoretical generalization. Therefore, the issue itself can be considered as a window on the new Systemics and its challenges.