Next Article in Journal
The Water Content Drives the Susceptibility of the Lichen Evernia prunastri and the Moss Brachythecium sp. to High Ozone Concentrations
Next Article in Special Issue
A Universal Model for the Log-Normal Distribution of Elasticity in Polymeric Gels and Its Relevance to Mechanical Signature of Biological Tissues
Previous Article in Journal
The Prevalence and Impact of Hepatic Steatosis on Response to Direct-Acting Antiviral Therapy in HIV–HCV Coinfection
Open AccessArticle

Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life

1
Laboratory AGEIS EA 7407, Faculty of Medicine, University of Grenoble Alpes, 38700 La Tronche, France
2
Future of Research Team, SimplissimA International Research Institute, 39 rue saint Louis, 11324 Port-Louis, Mauritius
*
Author to whom correspondence should be addressed.
Biology 2020, 9(5), 88; https://doi.org/10.3390/biology9050088
Received: 17 February 2020 / Revised: 6 April 2020 / Accepted: 19 April 2020 / Published: 25 April 2020
(This article belongs to the Special Issue Perspectives of Theoretical Medicine)
(1) Background: Previous experimental observations and theoretical hypotheses have been providing insight into a hypothetical world where an RNA hairpin or ring may have debuted as the primary informational and functional molecule. We propose a model revisiting the architecture of RNA-peptide interactions at the origin of life through the evolutionary dynamics of RNA populations. (2) Methods: By performing a step-by-step computation of the smallest possible hairpin/ring RNA sequences compatible with building up a variety of peptides of the primitive network, we inferred the sequence of a singular docosameric RNA molecule, we call the ALPHA sequence. Then, we searched for any relics of the peptides made from ALPHA in sequences deposited in the different public databases. (3) Results: Sequence matching between ALPHA and sequences from organisms among the earliest forms of life on Earth were found at high statistical relevance. We hypothesize that the frequency of appearance of relics from ALPHA sequence in present genomes has a functional necessity. (4) Conclusions: Given the fitness of ALPHA as a supportive sequence of the framework of all existing theories, and the evolution of Archaea and giant viruses, it is anticipated that the unique properties of this singular archetypal ALPHA sequence should prove useful as a model matrix for future applications, ranging from synthetic biology to DNA computing. View Full-Text
Keywords: origin of life; evolution; amino acid RNA interaction origin of life; evolution; amino acid RNA interaction
Show Figures

Figure 1

MDPI and ACS Style

Demongeot, J.; Henrion-Caude, A. Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life. Biology 2020, 9, 88. https://doi.org/10.3390/biology9050088

AMA Style

Demongeot J, Henrion-Caude A. Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life. Biology. 2020; 9(5):88. https://doi.org/10.3390/biology9050088

Chicago/Turabian Style

Demongeot, Jacques; Henrion-Caude, Alexandra. 2020. "Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life" Biology 9, no. 5: 88. https://doi.org/10.3390/biology9050088

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop