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Autophagy in Cancer Cell Death

by Benedikt Linder 1,* and Donat Kögel 1,2,*
Experimental Neurosurgery, Department of Neurosurgery, Neuroscience Center, Goethe University Hospital, 60528 Frankfurt am Main, Germany
German Cancer Consortium (DKTK), Partner Site Frankfurt, 60590 Frankfurt am Main, Germany
Authors to whom correspondence should be addressed.
Biology 2019, 8(4), 82;
Received: 2 September 2019 / Revised: 18 October 2019 / Accepted: 28 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue Autophagy in Cancer)
Autophagy has important functions in maintaining energy metabolism under conditions of starvation and to alleviate stress by removal of damaged and potentially harmful cellular components. Therefore, autophagy represents a pro-survival stress response in the majority of cases. However, the role of autophagy in cell survival and cell death decisions is highly dependent on its extent, duration, and on the respective cellular context. An alternative pro-death function of autophagy has been consistently observed in different settings, in particular, in developmental cell death of lower organisms and in drug-induced cancer cell death. This cell death is referred to as autophagic cell death (ACD) or autophagy-dependent cell death (ADCD), a type of cellular demise that may act as a backup cell death program in apoptosis-deficient tumors. This pro-death function of autophagy may be exerted either via non-selective bulk autophagy or excessive (lethal) removal of mitochondria via selective mitophagy, opening new avenues for the therapeutic exploitation of autophagy/mitophagy in cancer treatment. View Full-Text
Keywords: autophagy; cell death; cancer; gossypol; AT-101; mitophagy; mitochondria autophagy; cell death; cancer; gossypol; AT-101; mitophagy; mitochondria
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Linder, B.; Kögel, D. Autophagy in Cancer Cell Death. Biology 2019, 8, 82.

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