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Biology 2016, 5(3), 31;

Circadian Regulation of Synaptic Plasticity

Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University Spokane, Pharmaceutical and Biomedical Science Building 213, 412 E. Spokane Falls Blvd., Spokane, WA 99202, USA
Academic Editors: Christian Cajochen, Christina Schmidt and Sarah L. Chellappa
Received: 2 June 2016 / Revised: 24 June 2016 / Accepted: 4 July 2016 / Published: 13 July 2016
(This article belongs to the Special Issue Circadian Rhythms from Bench to Bedside)
Full-Text   |   PDF [509 KB, uploaded 13 July 2016]   |  


Circadian rhythms refer to oscillations in biological processes with a period of approximately 24 h. In addition to the sleep/wake cycle, there are circadian rhythms in metabolism, body temperature, hormone output, organ function and gene expression. There is also evidence of circadian rhythms in synaptic plasticity, in some cases driven by a master central clock and in other cases by peripheral clocks. In this article, I review the evidence for circadian influences on synaptic plasticity. I also discuss ways to disentangle the effects of brain state and rhythms on synaptic plasticity. View Full-Text
Keywords: circadian; clock; plasticity; sleep; state-clock model circadian; clock; plasticity; sleep; state-clock model

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Frank, M.G. Circadian Regulation of Synaptic Plasticity. Biology 2016, 5, 31.

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