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Fibers 2015, 3(4), 478-490;

Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma

Department of Chemistry and Physics, La Trobe University, Bundoora, Victoria 3086, Australia
International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Tsukuba 305-0044, Japan
Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-8571, Japan
Department of Material Science and Technology, Graduate School of Tokyo, University of Science, Tokyo 278-8510, Japan
Author to whom correspondence should be addressed.
Academic Editor: Jinlian Hu
Received: 30 September 2015 / Accepted: 30 October 2015 / Published: 6 November 2015
(This article belongs to the Special Issue Smart Textiles)
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In this paper we investigate a potential new treatment option for basal cell carcinoma using electrospun polymer nanofibers. Poly(ε-caprolactone) fibers incorporated with the anti-cancer drug imiquimod were successfully produced for the first time. These fibers were characterized and their diffusion release profile tested in vitro. A range of different electrospinning parameters were investigated in order to determine the most effective approach in optimizing the fibers for future in vivo testing. Characterization showed stable and homogeneous distribution of imiquimod. Although the drug was released faster than what would be needed to replicate the current treatment model, this system would ideally allow for a treatment option which reduces side effects and is more convenient for the patient than the current topical treatment. View Full-Text
Keywords: biodegradable nanofiber; poly(ε-caprolactone); imiquimod; anti-cancer fiber biodegradable nanofiber; poly(ε-caprolactone); imiquimod; anti-cancer fiber

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Garrett, R.; Niiyama, E.; Kotsuchibashi, Y.; Uto, K.; Ebara, M. Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma. Fibers 2015, 3, 478-490.

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