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Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity

Development of Silver Doped Hydroxyapatite Thin Films for Biomedical Applications

National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania
Department of Civil Engineering and Environment, Université d’Orléans, ISTO, UMR 7327 CNRS, 1A Rue de la Férollerie, 45071 Orléans, France
Global Center for Science and Engineering, Waseda University, Tokyo 169-8555, Japan
Stefan Nicolau Virology Institute, 030304 Bucharest, Romania
Life, Environmental and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB), University of Bucharest, 060023 Bucharest, Romania
Authors to whom correspondence should be addressed.
Academic Editor: Maria Cristina Tanzi
Coatings 2022, 12(3), 341;
Received: 15 January 2022 / Revised: 1 March 2022 / Accepted: 3 March 2022 / Published: 5 March 2022
(This article belongs to the Special Issue Hydroxyapatite Based Coatings for Biomedical Applications)
Silver doped hydroxyapatite [AgHAp, Ca10−xAg(PO4)6(OH)2], due to its antimicrobial properties, is an advantageous material to be used for various coatings. The AgHAp thin films with xAg = 0.05 and xAg = 0.1 were achieved using the spin-coating method. The resulting samples were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). XRD analysis revealed that the particles of both samples are ellipsoidal. Also, in agreement with the results obtained by XRD measurements, the results of the SEM studies have shown that the particles shape is ellipsoidal. Optical properties of silver doped hydroxyapatite thin films deposited on Si substrate were investigated through Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. The results obtained by the two complementary techniques highlighted that the molecular structure of the studied samples is not influenced by the increase of the silver concentration in the samples. Our studies revealed that the surface morphology of the obtained samples consist of uniform and continuous layers. The biocompatibility of the obtained thin films was also evaluated with the aid of human osteosarcoma MG63 (ATCC CRL 1427) cell line. Moreover, the in vitro antifungal activity against Candida albicans fungal strain of the AgHAp thin films was studied and the obtained results revealed their antifungal effect. The results of the biological assays showed that the AgHAp thin films are a very promising material for biomedical applications. View Full-Text
Keywords: silver; hydroxyapatite; thin films; biocompatibility; surface morphology silver; hydroxyapatite; thin films; biocompatibility; surface morphology
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MDPI and ACS Style

Iconaru, S.L.; Predoi, D.; Ciobanu, C.S.; Motelica-Heino, M.; Guegan, R.; Bleotu, C. Development of Silver Doped Hydroxyapatite Thin Films for Biomedical Applications. Coatings 2022, 12, 341.

AMA Style

Iconaru SL, Predoi D, Ciobanu CS, Motelica-Heino M, Guegan R, Bleotu C. Development of Silver Doped Hydroxyapatite Thin Films for Biomedical Applications. Coatings. 2022; 12(3):341.

Chicago/Turabian Style

Iconaru, Simona Liliana, Daniela Predoi, Carmen Steluta Ciobanu, Mikael Motelica-Heino, Régis Guegan, and Coralia Bleotu. 2022. "Development of Silver Doped Hydroxyapatite Thin Films for Biomedical Applications" Coatings 12, no. 3: 341.

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