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Article

Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity

1
National Institute of Materials Physics, 405A Atomistilor Street, 077125 Magurele, Romania
2
Department of Mechanics, University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania
3
HORIBA Jobin Yvon S.A.S., 6-18, Rue du Canal, CEDEX, 91165 Longjumeau, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Hideyuki Kanematsu
Coatings 2022, 12(3), 306; https://doi.org/10.3390/coatings12030306
Received: 24 January 2022 / Revised: 17 February 2022 / Accepted: 22 February 2022 / Published: 24 February 2022
(This article belongs to the Special Issue Hydroxyapatite Based Coatings for Biomedical Applications)
Owing to its unique biological and physicochemical properties, hydroxyapatite (HAp) represents one of the most extensively studied biomaterials for biomedical applications. It is well known that Candida is currently one of the fungi frequently involved in the onset and development of post-implant infections and, owing to the appearance of antifungal resistance, it is quite difficult to treat despite all the tremendous efforts made in this regard by the scientific world. Therefore, in this context, we report for the first time in this paper, the development and characterization of europium-doped thin films (5EuHAp, xEu = 0.05) on a Si substrate by a spin-coating method. The results of ultrasound (US), zeta (ζ) potential, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR) studies are presented. The XRD studies conducted on 5EuHAp suspension revealed the nanometric dimensions of the particles and sample purity. In addition, a moderate stability of the 5EuHAp suspension was observed. XPS measurements revealed the presence of Eu 3d in the 5EuHAp thin films. In the SEM micrographs, the surface uniformity and the absence of the surface defects could be observed. Moreover, the results of the FTIR studies showed the presence of the vibrational bands specific to the HAp structure in the studied sample. The antifungal activity of the HAp and 5EuHAp suspensions and coatings was evaluated using the Candida albicans ATCC 10231 (C. albicans) fungal strain. The qualitative assays of the antifungal properties of HAp and 5EuHAp coatings were also visualized by SEM and CLSM. The antifungal studies revealed that both 5EuHAp suspensions and coatings exhibited noticeable antifungal activity against C. albicans cells. View Full-Text
Keywords: europium; hydroxyapatite; antifungal properties; thin films; ultrasound measurements europium; hydroxyapatite; antifungal properties; thin films; ultrasound measurements
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MDPI and ACS Style

Ciobanu, C.S.; Predoi, M.V.; Buton, N.; Megier, C.; Iconaru, S.L.; Predoi, D. Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity. Coatings 2022, 12, 306. https://doi.org/10.3390/coatings12030306

AMA Style

Ciobanu CS, Predoi MV, Buton N, Megier C, Iconaru SL, Predoi D. Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity. Coatings. 2022; 12(3):306. https://doi.org/10.3390/coatings12030306

Chicago/Turabian Style

Ciobanu, Carmen Steluta, Mihai Valentin Predoi, Nicolas Buton, Christelle Megier, Simona Liliana Iconaru, and Daniela Predoi. 2022. "Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity" Coatings 12, no. 3: 306. https://doi.org/10.3390/coatings12030306

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