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Open AccessArticle

CeO2 Containing Thin Films as Bioactive Coatings for Orthopaedic Implants

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Faculty of Medical Engineering, University POLITEHNICA of Bucharest, RO-011061 Bucharest, Romania
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Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, RO-011061 Bucharest, Romania
3
Horia Hulubei National Institute of Physics and Nuclear Engineering, RO-077125 Magurele, Romania
*
Author to whom correspondence should be addressed.
Coatings 2020, 10(7), 642; https://doi.org/10.3390/coatings10070642
Received: 1 June 2020 / Revised: 24 June 2020 / Accepted: 29 June 2020 / Published: 30 June 2020
(This article belongs to the Section Bioactive Coatings and Biointerfaces)
Due to the fact of their ability to bond with human’s hard tissue, bioglasses have gained interest in the biomedical field with certain purposes regarding their usage in the replacement, healing or repair of bones. In the form of thin films, they trigger an increase in biocompatibility for the inert supports after implantation, based on surface engineering to ensure osteoinduction. For that, this research is focused on obtaining coatings based on cerium-enriched bioglass to generate bioactive and potential additional antimicrobial and antioxidant properties. The addressed oxide system was a novel and complex one, 46.10 SiO2–2.60 P2O5–16.90 CaO–10.00 MgO–19.40 Na2O–5.00 CeO2 (mol%), while two different synthesis methods, laser ablation and spin coating, were tackled comparatively. In the case of the first technique, substrate temperature was selected as variable parameter (room temperature or 300 °C). After conducting a complex characterization, films’ deposition was validated, their bioactive behaviour was proven by the formation of calcium phosphate after immersion in simulated body fluid for four weeks, while the impact exerted on the tested human fibroblast BJ cells (ATCC, CRL-2522) confirmed the applicative potential. View Full-Text
Keywords: cerium dioxide; thin films; laser ablation; spin coating; bioactivity; Escherichia coli; fibroblast cells cerium dioxide; thin films; laser ablation; spin coating; bioactivity; Escherichia coli; fibroblast cells
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Prefac, G.-A.; Milea, M.-L.; Vadureanu, A.-M.; Muraru, S.; Dobrin, D.-I.; Isopencu, G.-O.; Jinga, S.-I.; Raileanu, M.; Bacalum, M.; Busuioc, C. CeO2 Containing Thin Films as Bioactive Coatings for Orthopaedic Implants. Coatings 2020, 10, 642.

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