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Open AccessFeature PaperArticle

Use of the Sol–Gel Method for the Preparation of Coatings of Titanium Substrates with Hydroxyapatite for Biomedical Application

1
Department of Engineering, University of Campania “Luigi Vanvitelli”, Via Roma 29, I-813031 Aversa, Italy
2
Department of Civil Engineering and Architecture and UdR-Catania Consorzio INSTM, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
3
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, Italy
*
Author to whom correspondence should be addressed.
Coatings 2020, 10(3), 203; https://doi.org/10.3390/coatings10030203
Received: 27 December 2019 / Revised: 15 February 2020 / Accepted: 24 February 2020 / Published: 26 February 2020
Hydroxyapatite (HA) was coated onto the surface of commercially pure titanium grade 4 (a material generally used for implant application) by a dip coating method using HA sol. Hydroxyapatite sol was synthesized via sol–gel using Ca(NO3)2∙4H2O and P2O5 as precursors. The surface of the HA coating was homogeneous, as determined by scanning electron microscopy (SEM), attenuated total reflectance Fourier transform infrared (ATR-FTIR), and X-ray diffraction (XRD), which allowed the materials to be characterized. The bioactivity of the synthesized materials and their efficiency for use as future bone implants was confirmed by observing the formation of a layer of hydroxyapatite on the surface of the samples soaked in a fluid simulating the composition of human blood plasma. To verify the biocompatibility of the obtained biomaterial, fibroblasts were grown on a glass surface and were tested for viability after 24 h. The results of the WST-8 analysis suggest that the HA systems, prepared by the sol–gel method, are most suitable for modifying the surface of titanium implants and improving their biocompatibility. View Full-Text
Keywords: sol–gel synthesis; hydroxyapatite; titanium substrate coating; biocompatibility sol–gel synthesis; hydroxyapatite; titanium substrate coating; biocompatibility
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Catauro, M.; Barrino, F.; Blanco, I.; Piccolella, S.; Pacifico, S. Use of the Sol–Gel Method for the Preparation of Coatings of Titanium Substrates with Hydroxyapatite for Biomedical Application. Coatings 2020, 10, 203.

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