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Open AccessArticle

Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device

1
School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
2
School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
3
School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK
4
School of Life and Medical Sciences, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK
5
Institut de Chimie et des Matériaux Paris-Est (ICMPE), Systèmes Polymères Complexes, UMR CNRS 7182, 2-8 rue Henri Dunant, 94320 Thiais, France
6
Department of Pharmacy, University of Genoa, Viale Benedetto XV 3, 16132 Genoa, Italy
7
Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark
*
Authors to whom correspondence should be addressed.
Ambra Vestri and Amanda K. Pearce contributed equally to this work.
Coatings 2020, 10(2), 125; https://doi.org/10.3390/coatings10020125
Received: 17 January 2020 / Revised: 28 January 2020 / Accepted: 29 January 2020 / Published: 1 February 2020
(This article belongs to the Special Issue Bio-Based Active Packaging for Shelf Life Extension)
Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery. View Full-Text
Keywords: starch; nanoparticles; drug delivery; polymer; poly(glycerol-adipate); biomaterial; biocompatible; nanocomposites starch; nanoparticles; drug delivery; polymer; poly(glycerol-adipate); biomaterial; biocompatible; nanocomposites
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MDPI and ACS Style

Vestri, A.; Pearce, A.K.; Cavanagh, R.; Styliari, I.D.; Sanders, C.; Couturaud, B.; Schenone, S.; Taresco, V.; Jakobsen, R.R.; Howdle, S.M.; Musumeci, F.; Sagnelli, D. Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device. Coatings 2020, 10, 125. https://doi.org/10.3390/coatings10020125

AMA Style

Vestri A, Pearce AK, Cavanagh R, Styliari ID, Sanders C, Couturaud B, Schenone S, Taresco V, Jakobsen RR, Howdle SM, Musumeci F, Sagnelli D. Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device. Coatings. 2020; 10(2):125. https://doi.org/10.3390/coatings10020125

Chicago/Turabian Style

Vestri, Ambra; Pearce, Amanda K.; Cavanagh, Robert; Styliari, Ioanna D.; Sanders, Carlos; Couturaud, Benoit; Schenone, Silvia; Taresco, Vincenzo; Jakobsen, Rasmus R.; Howdle, Steven M.; Musumeci, Francesca; Sagnelli, Domenico. 2020. "Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device" Coatings 10, no. 2: 125. https://doi.org/10.3390/coatings10020125

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