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Article

Aging Effect on Functionalized Silver-Based Nanocoating Braided Coronary Stents

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2C2T-Centre for Textile Science and Technology, University of Minho, 4800-058 Guimarães, Portugal
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CFUM-UP, Physics Department, Campus of Azurém, University of Minho, 4800-058 Guimarães, Portugal
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CEB, Centre of Biological Engineering, Campus de Gualtar, University of Minho, 4710-335 Braga, Portugal
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SEG-CEMMPRE Mechanical Engineering Department, University of Coimbra, 3030-788 Coimbra, Portugal
*
Author to whom correspondence should be addressed.
Coatings 2020, 10(12), 1234; https://doi.org/10.3390/coatings10121234
Received: 11 November 2020 / Revised: 7 December 2020 / Accepted: 10 December 2020 / Published: 16 December 2020
(This article belongs to the Special Issue Functional Coatings for Textile Applications)
A previously developed fiber-based polyester (PES) stent, with mechanical properties comparable to commercial nitinol stents, was coated with metallic silver (Ag0) and silver oxides (AgxO) thin films through direct current (DC) magnetron sputtering. Ag0 and AgxO coatings provide antimicrobial properties to the stents to minimize the occurrence of coronary stent infections. Nevertheless, the stent interacts with the atmosphere and then with the biological fluids and may lead to the generation of silver species with diminished antimicrobial efficiency and/or prone to induce cytotoxicity. Therefore, stent coating nanostructures aged 3 months were thoroughly analyzed by X-ray photoelectron spectroscopy (XPS) and their antimicrobial and cytotoxicity properties were assessed. Aging led to the presence of silver carbonate and bicarbonate as well as chemisorbed oxygen species in Ag0 and AgxO coatings. Bactericidal efficacy was tested against an important nosocomial bacterium, particularly associated to indwelling devices: Staphylococcus epidermidis. Aged Ag0 and AgxO coating presented a Log reduction of 1 and 2 at their surface; respectively. However, aged stents were able to induce a Log reduction of 2 (Ag0) and 4 (AgxO) on the surrounding medium. Only aged AgxO stent was able to provide a mild reduction of the bacterium at its surface and a clear antimicrobial effect (Log reduction >3) within its vicinity. More importantly, both aged Ag0 and AgxO stents were shown to be compatible with fibroblasts cells indicating that they can be safely used as indwelling devices, despite the aging effect. View Full-Text
Keywords: stent; silver; textile; direct current magnetron sputtering; X-ray photoelectron spectroscopy; bactericidal; cytotoxicity stent; silver; textile; direct current magnetron sputtering; X-ray photoelectron spectroscopy; bactericidal; cytotoxicity
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MDPI and ACS Style

Rebelo, R.; Padrão, J.; Fernandes, M.M.; Carvalho, S.; Henriques, M.; Zille, A.; Fangueiro, R. Aging Effect on Functionalized Silver-Based Nanocoating Braided Coronary Stents. Coatings 2020, 10, 1234. https://doi.org/10.3390/coatings10121234

AMA Style

Rebelo R, Padrão J, Fernandes MM, Carvalho S, Henriques M, Zille A, Fangueiro R. Aging Effect on Functionalized Silver-Based Nanocoating Braided Coronary Stents. Coatings. 2020; 10(12):1234. https://doi.org/10.3390/coatings10121234

Chicago/Turabian Style

Rebelo, Rita, Jorge Padrão, Margarida M. Fernandes, Sandra Carvalho, Mariana Henriques, Andrea Zille, and Raul Fangueiro. 2020. "Aging Effect on Functionalized Silver-Based Nanocoating Braided Coronary Stents" Coatings 10, no. 12: 1234. https://doi.org/10.3390/coatings10121234

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