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Article

Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series

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Wound Care Unit, Department of Internal Medicine, 50586, Kuala Lumpur Hospital, Kuala Lumpur 50586, Malaysia
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General Practitioner Xanthi, 67100 Xanthi, Greece
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Hospital Na Pleši (Nemocnice Na Pleši s. r. o.), Complex Rehabilitation Center, 262 04 Nová Ves pod Pleší, Czech Republic
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Hospital Na Pleši (Nemocnice Na Pleši s. r. o.), Surgical clinic, 262 04 Nová Ves pod Pleší, Czech Republic
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Triticum Exploitatie BV, 6222NK Maastricht, The Netherlands
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Author to whom correspondence should be addressed.
Antibiotics 2020, 9(9), 529; https://doi.org/10.3390/antibiotics9090529
Received: 7 July 2020 / Revised: 14 August 2020 / Accepted: 17 August 2020 / Published: 19 August 2020
Diabetic ulcers are at risk of becoming chronic and infected, as diabetics have hampered vascular structures, limiting oxygen and nutrient supply. These wounds can lead to pain, malodor, functional problems, and amputation. The current rise in antibiotic resistance demands for complementary therapies. Medical-grade honey (MGH) forms an attractive option because of its antimicrobial and pro-healing properties. We aim to show the beneficial effects of MGH in infected diabetic ulcers. We present six patients with infected diabetic ulcers, of which some were at risk of (further) amputation. Previous treatments with antibiotics, silver and alginate dressings, surgical closure, and maggot therapy were ineffective; therefore, the treatment was switched to the application of MGH. MGH therapy typically reduced the malodor in a couple of days and controlled infection within 2–3 weeks. MGH also enhanced wound healing by promoting granulation tissue formation, angiogenesis, and re-epithelialization, by decreasing inflammatory and oxidative stress and providing nutrients. Together, wound healing was enhanced, and the patient’s quality of life improved. MGH is safe and cost-effective for treating complicated diabetic wounds with (antibiotic-resistant) infections and at risk of amputation. MGH forms a promising alternative or complementary therapy to replace antibiotics for treating locally infected wounds. View Full-Text
Keywords: diabetic ulcers; antibiotic resistance; infections; medical-grade honey; complementary therapies diabetic ulcers; antibiotic resistance; infections; medical-grade honey; complementary therapies
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MDPI and ACS Style

Nair, H.K.R.; Tatavilis, N.; Pospíšilová, I.; Kučerová, J.; Cremers, N.A.J. Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series. Antibiotics 2020, 9, 529. https://doi.org/10.3390/antibiotics9090529

AMA Style

Nair HKR, Tatavilis N, Pospíšilová I, Kučerová J, Cremers NAJ. Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series. Antibiotics. 2020; 9(9):529. https://doi.org/10.3390/antibiotics9090529

Chicago/Turabian Style

Nair, Harikrishna K.R., Nektarios Tatavilis, Ivana Pospíšilová, Jana Kučerová, and Niels A.J. Cremers 2020. "Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series" Antibiotics 9, no. 9: 529. https://doi.org/10.3390/antibiotics9090529

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