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Open AccessReview

A Review of Topical Phage Therapy for Chronically Infected Wounds and Preparations for a Randomized Adaptive Clinical Trial Evaluating Topical Phage Therapy in Chronically Infected Diabetic Foot Ulcers

Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
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Antibiotics 2020, 9(7), 377; https://doi.org/10.3390/antibiotics9070377
Received: 8 May 2020 / Revised: 20 June 2020 / Accepted: 24 June 2020 / Published: 4 July 2020
The advent and increasing prevalence of antimicrobial resistance commensurate with the absence of novel antibiotics on the horizon raises the specter of untreatable infections. Phages have been safely administered to thousands of patients exhibiting signals of efficacy in many experiencing infections refractory to antecedent antibiotics. Topical phage therapy may represent a convenient and efficacious treatment modality for chronic refractory infected cutaneous wounds spanning all classifications including venous stasis, burn-mediated, and diabetic ulcers. We will initially provide results from a systematic literature review of topical phage therapy used clinically in refractorily infected chronic wounds. We will then segue into a synopsis of the preparations for a forthcoming phase II a randomized placebo-controlled clinical trial assessing the therapeutic efficacy exploiting adjunctive personalized phage administration, delivered topically, intravenously (IV) and via a combination of both modalities (IV + topical) in the treatment of infected diabetic foot ulcers (perhaps the canonical paradigm representing complicated recalcitrant infected cutaneous wounds). View Full-Text
Keywords: bacteriophage; wounds; ulcers; topical; infected ulcers; infected wounds; topical therapeutics; phage library; phage-antibiotic synergy; phage-phage synergy; and antibiotics bacteriophage; wounds; ulcers; topical; infected ulcers; infected wounds; topical therapeutics; phage library; phage-antibiotic synergy; phage-phage synergy; and antibiotics
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MDPI and ACS Style

Duplessis, C.A.; Biswas, B. A Review of Topical Phage Therapy for Chronically Infected Wounds and Preparations for a Randomized Adaptive Clinical Trial Evaluating Topical Phage Therapy in Chronically Infected Diabetic Foot Ulcers. Antibiotics 2020, 9, 377. https://doi.org/10.3390/antibiotics9070377

AMA Style

Duplessis CA, Biswas B. A Review of Topical Phage Therapy for Chronically Infected Wounds and Preparations for a Randomized Adaptive Clinical Trial Evaluating Topical Phage Therapy in Chronically Infected Diabetic Foot Ulcers. Antibiotics. 2020; 9(7):377. https://doi.org/10.3390/antibiotics9070377

Chicago/Turabian Style

Duplessis, Christopher A.; Biswas, Biswajit. 2020. "A Review of Topical Phage Therapy for Chronically Infected Wounds and Preparations for a Randomized Adaptive Clinical Trial Evaluating Topical Phage Therapy in Chronically Infected Diabetic Foot Ulcers" Antibiotics 9, no. 7: 377. https://doi.org/10.3390/antibiotics9070377

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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