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Review

Multimodal Role of Amino Acids in Microbial Control and Drug Development

1
Faculty of Science and Technology, University of Wolverhampton, Wolverhampton WV1 1LY, UK
2
Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(6), 330; https://doi.org/10.3390/antibiotics9060330
Received: 6 May 2020 / Revised: 9 June 2020 / Accepted: 16 June 2020 / Published: 17 June 2020
(This article belongs to the Special Issue Novel Strategies to Control Antimicrobial Resistance)
Amino acids are ubiquitous vital biomolecules found in all kinds of living organisms including those in the microbial world. They are utilised as nutrients and control many biological functions in microorganisms such as cell division, cell wall formation, cell growth and metabolism, intermicrobial communication (quorum sensing), and microbial-host interactions. Amino acids in the form of enzymes also play a key role in enabling microbes to resist antimicrobial drugs. Antimicrobial resistance (AMR) and microbial biofilms are posing a great threat to the world’s human and animal population and are of prime concern to scientists and medical professionals. Although amino acids play an important role in the development of microbial resistance, they also offer a solution to the very same problem i.e., amino acids have been used to develop antimicrobial peptides as they are highly effective and less prone to microbial resistance. Other important applications of amino acids include their role as anti-biofilm agents, drug excipients, drug solubility enhancers, and drug adjuvants. This review aims to explore the emerging paradigm of amino acids as potential therapeutic moieties. View Full-Text
Keywords: amino acids; antimicrobial resistance; quorum sensing; microbial biofilm; solubility; excipients; adjuvants amino acids; antimicrobial resistance; quorum sensing; microbial biofilm; solubility; excipients; adjuvants
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MDPI and ACS Style

Idrees, M.; Mohammad, A.R.; Karodia, N.; Rahman, A. Multimodal Role of Amino Acids in Microbial Control and Drug Development. Antibiotics 2020, 9, 330. https://doi.org/10.3390/antibiotics9060330

AMA Style

Idrees M, Mohammad AR, Karodia N, Rahman A. Multimodal Role of Amino Acids in Microbial Control and Drug Development. Antibiotics. 2020; 9(6):330. https://doi.org/10.3390/antibiotics9060330

Chicago/Turabian Style

Idrees, Muhammad, Afzal R. Mohammad, Nazira Karodia, and Ayesha Rahman. 2020. "Multimodal Role of Amino Acids in Microbial Control and Drug Development" Antibiotics 9, no. 6: 330. https://doi.org/10.3390/antibiotics9060330

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