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Open AccessArticle

Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327

1
Center for Biodiversity and Drug Discovery, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama City 0843-01103, Panama
2
Department of Microbiology and Parasitology, College of Natural, Exact Sciences, and Technology, Universidad de Panama, Panama City 0824-03366, Panama
3
Smithsonian Tropical Research Institute, Panama City 0843-03092, Panama
4
Department of Biochemistry, College of Natural, Exact Sciences, and Technology, University of Panama, Panama City 0824-03366, Panama
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Antibiotics 2020, 9(12), 923; https://doi.org/10.3390/antibiotics9120923
Received: 29 October 2020 / Revised: 10 December 2020 / Accepted: 16 December 2020 / Published: 18 December 2020
(This article belongs to the Special Issue Natural Compounds as Antimicrobial Agents, 2nd Volume)
The present research aimed to evaluate the antibacterial activity of volatile organic compounds (VOCs) produced by octocoral-associated bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327. The volatilome bioactivity of both bacteria species was evaluated against human pathogenic antibiotic-resistant bacteria, methicillin-resistant Staphylococcus aureus, Acinetobacter baumanni, and Pseudomonas aeruginosa. In this regard, the in vitro tests showed that Bacillus sp. BO53 VOCs inhibited the growth of P. aeruginosa and reduced the growth of S. aureus and A. baumanni. Furthermore, Pseudoalteromonas sp. GA327 strongly inhibited the growth of A. baumanni, and P. aeruginosa. VOCs were analyzed by headspace solid-phase microextraction (HS-SPME) joined to gas chromatography-mass spectrometry (GC-MS) methodology. Nineteen VOCs were identified, where 5-acetyl-2-methylpyridine, 2-butanone, and 2-nonanone were the major compounds identified on Bacillus sp. BO53 VOCs; while 1-pentanol, 2-butanone, and butyl formate were the primary volatile compounds detected in Pseudoalteromonas sp. GA327. We proposed that the observed bioactivity is mainly due to the efficient inhibitory biochemical mechanisms of alcohols and ketones upon antibiotic-resistant bacteria. This is the first report which describes the antibacterial activity of VOCs emitted by octocoral-associated bacteria. View Full-Text
Keywords: octocoral-associated bacteria; antibacterial activity; volatilome; Bacillus; Pseudoalteromonas; bacteria volatile organic compounds; antibiotic-resistant bacteria octocoral-associated bacteria; antibacterial activity; volatilome; Bacillus; Pseudoalteromonas; bacteria volatile organic compounds; antibiotic-resistant bacteria
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MDPI and ACS Style

Garrido, A.; Atencio, L.A.; Bethancourt, R.; Bethancourt, A.; Guzmán, H.; Gutiérrez, M.; Durant-Archibold, A.A. Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327. Antibiotics 2020, 9, 923. https://doi.org/10.3390/antibiotics9120923

AMA Style

Garrido A, Atencio LA, Bethancourt R, Bethancourt A, Guzmán H, Gutiérrez M, Durant-Archibold AA. Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327. Antibiotics. 2020; 9(12):923. https://doi.org/10.3390/antibiotics9120923

Chicago/Turabian Style

Garrido, Anette; Atencio, Librada A.; Bethancourt, Rita; Bethancourt, Ariadna; Guzmán, Héctor; Gutiérrez, Marcelino; Durant-Archibold, Armando A. 2020. "Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327" Antibiotics 9, no. 12: 923. https://doi.org/10.3390/antibiotics9120923

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