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Volume 9
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10.3390/antibiotics9100674
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Article

The Antibacterial and Anti-Biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas aeruginosa from Irish Cystic Fibrosis Patients

by
Megan O’Shaughnessy
1,2,
Pauraic McCarron
2,
Livia Viganor
2,
Malachy McCann
3,
Michael Devereux
2 and
Orla Howe
1,2,*
1
School of Biological and Health Sciences, Technological University Dublin-City Campus, 9, D09 V209 Dublin, Ireland
2
Centre for Biomemtic and Therapeutic Research, FOCAS Research Institute, Technological University Dublin-City Campus, 9, D09 V209 Dublin, Ireland
3
Chemistry Department, National University of Ireland-Maynooth, W23 F2K8 Kildare, Ireland
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(10), 674; https://doi.org/10.3390/antibiotics9100674
Submission received: 16 September 2020 / Revised: 29 September 2020 / Accepted: 1 October 2020 / Published: 5 October 2020
(This article belongs to the Special Issue Development of Effective Antibacterial Treatment: Lessons from the Past and Novel Approaches)
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Abstract

Chronic infections of Pseudomonas aeruginosa in the lungs of cystic fibrosis (CF) patients are problematic in Ireland where inherited CF is prevalent. The bacteria’s capacity to form a biofilm in its pathogenesis is highly virulent and leads to decreased susceptibility to most antibiotic treatments. Herein, we present the activity profiles of the Cu(II), Mn(II) and Ag(I) tdda-phen chelate complexes {[Cu(3,6,9-tdda)(phen)2]·3H2O·EtOH}n (Cu-tdda-phen), {[Mn(3,6,9-tdda)(phen)2]·3H2O·EtOH}n (Mn-tdda-phen) and [Ag2(3,6,9-tdda)(phen)4]·EtOH (Ag-tdda-phen) (tddaH2 = 3,6,9-trioxaundecanedioic acid; phen = 1,10-phenanthroline) towards clinical isolates of P. aeruginosa derived from Irish CF patients in comparison to two reference laboratory strains (ATCC 27853 and PAO1). The effects of the metal-tdda-phen complexes and gentamicin on planktonic growth, biofilm formation (pre-treatment) and mature biofilm (post-treatment) alone and in combination were investigated. The effects of the metal-tdda-phen complexes on the individual biofilm components; exopolysaccharide, extracellular DNA (eDNA), pyocyanin and pyoverdine are also presented. All three metal-tdda-phen complexes showed comparable and often superior activity to gentamicin in the CF strains, compared to their activities in the laboratory strains, with respect to both biofilm formation and established biofilms. Combination studies presented synergistic activity between all three complexes and gentamicin, particularly for the post-treatment of established mature biofilms, and was supported by the reduction of the individual biofilm components examined.
Keywords: Pseudomonas aeruginosa; biofilm; metal complexes; 3,6,9-trioxaundecanedioic acid; 1,10-phenanthroline Pseudomonas aeruginosa; biofilm; metal complexes; 3,6,9-trioxaundecanedioic acid; 1,10-phenanthroline

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MDPI and ACS Style

O’Shaughnessy, M.; McCarron, P.; Viganor, L.; McCann, M.; Devereux, M.; Howe, O. The Antibacterial and Anti-Biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas aeruginosa from Irish Cystic Fibrosis Patients. Antibiotics 2020, 9, 674. https://doi.org/10.3390/antibiotics9100674

AMA Style

O’Shaughnessy M, McCarron P, Viganor L, McCann M, Devereux M, Howe O. The Antibacterial and Anti-Biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas aeruginosa from Irish Cystic Fibrosis Patients. Antibiotics. 2020; 9(10):674. https://doi.org/10.3390/antibiotics9100674

Chicago/Turabian Style

O’Shaughnessy, Megan, Pauraic McCarron, Livia Viganor, Malachy McCann, Michael Devereux, and Orla Howe. 2020. "The Antibacterial and Anti-Biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas aeruginosa from Irish Cystic Fibrosis Patients" Antibiotics 9, no. 10: 674. https://doi.org/10.3390/antibiotics9100674

APA Style

O’Shaughnessy, M., McCarron, P., Viganor, L., McCann, M., Devereux, M., & Howe, O. (2020). The Antibacterial and Anti-Biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of Pseudomonas aeruginosa from Irish Cystic Fibrosis Patients. Antibiotics, 9(10), 674. https://doi.org/10.3390/antibiotics9100674

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