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Antibiotics
Volume 9
Issue 1
10.3390/antibiotics9010010
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Article

Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans

by
Olena P. Ishchuk
1,2,
Olov Sterner
2,
Ulf Ellervik
2 and
Sophie Manner
2,*
1
Department of Biology, Lund University, Sölvegatan 35, SE-223 62 Lund, Sweden
2
Centre for Analysis and Synthesis, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(1), 10; https://doi.org/10.3390/antibiotics9010010
Received: 14 November 2019 / Revised: 4 December 2019 / Accepted: 24 December 2019 / Published: 30 December 2019
(This article belongs to the Section Novel Antimicrobial Agents)
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Abstract

The opportunistic human fungal pathogen Candida albicans relies on cell morphological transitions to develop biofilm and invade the host. In the current study, we developed new regulatory molecules, which inhibit the morphological transition of C. albicans from yeast-form cells to cells forming hyphae. These compounds, benzyl α-l-fucopyranoside and benzyl β-d-xylopyranoside, inhibit the hyphae formation and adhesion of C. albicans to a polystyrene surface, resulting in a reduced biofilm formation. The addition of cAMP to cells treated with α-l-fucopyranoside restored the yeast-hyphae switch and the biofilm level to that of the untreated control. In the β-d-xylopyranoside treated cells, the biofilm level was only partially restored by the addition of cAMP, and these cells remained mainly as yeast-form cells. View Full-Text
Keywords: fucoside; xyloside; Candida albicans; biofilm fucoside; xyloside; Candida albicans; biofilm
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Ishchuk, O.P.; Sterner, O.; Ellervik, U.; Manner, S. Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans. Antibiotics 2020, 9, 10. https://doi.org/10.3390/antibiotics9010010

AMA Style

Ishchuk OP, Sterner O, Ellervik U, Manner S. Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans. Antibiotics. 2020; 9(1):10. https://doi.org/10.3390/antibiotics9010010

Chicago/Turabian Style

Ishchuk, Olena P., Olov Sterner, Ulf Ellervik, and Sophie Manner. 2020. "Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans" Antibiotics 9, no. 1: 10. https://doi.org/10.3390/antibiotics9010010

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