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Open AccessArticle

Antifungal Agents Based on Chitosan Oligomers, ε-polylysine and Streptomyces spp. Secondary Metabolites against Three Botryosphaeriaceae Species

1
Departamento de Ingeniería Agroforestal, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia, Spain
2
Instituto Tecnológico Agrario de Castilla y León, Unidad de Cultivos Leñosos y Hortícolas, Ctra. De Burgos km 119, Finca Zamadueñas, 47071 Valladolid, Spain
3
Departamento de Microbiología y Genética, Facultad de Biología, Universidad de Salamanca, Campus Miguel de Unamuno, C/ Donantes de Sangre, s/n, 37007 Salamanca, Spain
4
Instituto Universitario de Investigación en Ciencias Ambientales de Aragón (IUCA), EPS, Universidad de Zaragoza, Carretera de Cuarte, s/n, 22071 Huesca, Spain
5
Servicio de Microbiología y Parasitología, Hospital Universitario Rio Hortega, SACYL, Calle Dulzaina, 2, 47012 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(3), 99; https://doi.org/10.3390/antibiotics8030099
Received: 30 June 2019 / Revised: 16 July 2019 / Accepted: 18 July 2019 / Published: 20 July 2019
(This article belongs to the Special Issue Natural Compounds as Antimicrobial Agents)
Grapevine trunk diseases (GTDs) are a major threat to the wine and grape industry. The aim of the study was to investigate the antifungal activity against Neofusicoccum parvum, Diplodia seriata, and Botryosphaeria dothidea of ε-polylysine, chitosan oligomers, their conjugates, Streptomyces rochei and S. lavendofoliae culture filtrates, and their binary mixtures with chitosan oligomers. In vitro mycelial growth inhibition tests suggest that the efficacy of these treatments, in particular those based on ε-polylysine and ε-polylysine:chitosan oligomers 1:1 w/w conjugate, against the three Botryosphaeriaceae species would be comparable to or higher than that of conventional synthetic fungicides. In the case of ε-polylysine, EC90 values as low as 227, 26.9, and 22.5 µg·mL−1 were obtained for N. parvum, D. seriata, and B. dothidea, respectively. Although the efficacy of the conjugate was slightly lower, with EC90 values of 507.5, 580.2, and 497.4 µg·mL−1, respectively, it may represent a more cost-effective option to the utilization of pure ε-polylysine. The proposed treatments may offer a viable and sustainable alternative for controlling GTDs. View Full-Text
Keywords: Botryosphaeria dothidea; conjugate complexes; Diplodia seriata; grapevine trunk diseases; Neofusicoccum parvum Botryosphaeria dothidea; conjugate complexes; Diplodia seriata; grapevine trunk diseases; Neofusicoccum parvum
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MDPI and ACS Style

Buzón-Durán, L.; Martín-Gil, J.; Pérez-Lebeña, E.; Ruano-Rosa, D.; Revuelta, J.L.; Casanova-Gascón, J.; Ramos-Sánchez, M.C.; Martín-Ramos, P. Antifungal Agents Based on Chitosan Oligomers, ε-polylysine and Streptomyces spp. Secondary Metabolites against Three Botryosphaeriaceae Species. Antibiotics 2019, 8, 99. https://doi.org/10.3390/antibiotics8030099

AMA Style

Buzón-Durán L, Martín-Gil J, Pérez-Lebeña E, Ruano-Rosa D, Revuelta JL, Casanova-Gascón J, Ramos-Sánchez MC, Martín-Ramos P. Antifungal Agents Based on Chitosan Oligomers, ε-polylysine and Streptomyces spp. Secondary Metabolites against Three Botryosphaeriaceae Species. Antibiotics. 2019; 8(3):99. https://doi.org/10.3390/antibiotics8030099

Chicago/Turabian Style

Buzón-Durán, Laura; Martín-Gil, Jesús; Pérez-Lebeña, Eduardo; Ruano-Rosa, David; Revuelta, José L.; Casanova-Gascón, José; Ramos-Sánchez, M. C.; Martín-Ramos, Pablo. 2019. "Antifungal Agents Based on Chitosan Oligomers, ε-polylysine and Streptomyces spp. Secondary Metabolites against Three Botryosphaeriaceae Species" Antibiotics 8, no. 3: 99. https://doi.org/10.3390/antibiotics8030099

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