Severe Type of Minocycline-Induced Hyperpigmentation Mimicking Peripheral Arterial Occlusive Disease in a Bullous Pemphigoid Patient
Abstract
:1. Introduction
2. Case Presentation
3. Discussion
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
- Geria, A.N.; Tajirian, A.L.; Kihiczak, G.; Schwartz, R.A. Minocycline-induced skin pigmentation: An update. Acta Derm. Croat. ADC 2009, 17, 123–126. [Google Scholar]
- Ochsendorf, F. Minocycline in Acne Vulgaris: Benefits and Risks. Am. J. Clin. Derm. 2010, 11, 327–341. [Google Scholar] [CrossRef] [PubMed]
- Maffeis, L.; Veraldi, S. Minocycline in the treatment of acne: Latest findings. G. Ital. Dermatol. Venereol. 2010, 145, 425–429. [Google Scholar] [PubMed]
- Garner, S.E.; Eady, E.A.; Popescu, C.; Newton, J.; Li, W.A. Minocycline for acne vulgaris: Efficacy and safety. Cochrane Database Syst. Rev. 2003, CD002086. [Google Scholar]
- Dutta, K.; Basu, A. Use of minocycline in viral infections. Indian J. Med. Res. 2011, 133, 467–470. [Google Scholar] [PubMed]
- Bryskier, A. Bacillus anthracis and antibacterial agents. Clin. Microbiol. Infect. 2002, 8, 467–478. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Romanowski, B.; Talbot, H.; Stadnyk, M.; Kowalchuk, P.; Bowie, W.R. Minocycline Compared with Doxycycline in the Treatment of Nongonococcal Urethritis and Mucopurulent Cervicitis. Ann. Intern. Med. 1993, 119, 16. [Google Scholar] [CrossRef]
- Zarzuelo, A.; Galvez, J.; Garrido-Mesa, N.; Garrido-Mesa, N. Minocycline: Far beyond an antibiotic. Br. J. Pharmacol. 2013, 169, 337–352. [Google Scholar]
- Dwyer, C.; Cuddihy, A.; Kerr, R.; Chapman, R.; Allam, B. Skin pigmentation due to minocycline treatment of facial dermatoses. Br. J. Dermatol. 1993, 129, 158–162. [Google Scholar] [CrossRef]
- Hanada, Y.; Berbari, E.F.; Steckelberg, J.M. Minocycline-Induced Cutaneous Hyperpigmentation in an Orthopedic Patient Population. Open Forum Infect. Dis. 2016, 3, 107. [Google Scholar] [CrossRef]
- O’Dell, J.R.; Paulsen, G.; Haire, C.E.; Blakely, K.; Palmer, W.; Wees, S.; Eckhoff, P.J.; Klassen, L.W.; Churchill, M.; Doud, D.; et al. Treatment of early seropositive rheumatoid arthritis with minocycline: Four-year followup of a double-blind, placebo-controlled trial. Arthritis Rheum. 1999, 42, 1691–1695. [Google Scholar] [CrossRef]
- Gordon, G. Hyperpigmentation of the skin associated with minocycline therapy. Arch. Dermatol. 1985, 121, 618–623. [Google Scholar] [CrossRef] [PubMed]
- Krause, W. Drug-induced hperpigemntation: A systematic review. J. Dtsch. Dermatol. Ges. 2013, 11, 644–651. [Google Scholar] [CrossRef] [PubMed]
- Sato, E.; Tsukimoto, M.; Shimura, N.; Awaya, A.; Kojima, S. Mechanism of Pigmentation by Minocycline in Murine B16 Melanoma Cells. Yakugaku Zasshi 2011, 131, 731–738. [Google Scholar] [CrossRef] [PubMed]
- Sato, S.; Murphy, G.F.; Bernhard, J.D.; Mihm, M.C., Jr.; Fitzpatrick, T.B. Ultrastructural and X-Ray Microanalytical Observations of Minocycline-Related Hyperpigmentation of the Skin. J. Invest. Derm. 1981, 77, 264–271. [Google Scholar] [CrossRef] [PubMed]
- Mouton, R.W.; Jordaan, H.F.; Schneider, J. A new type of minocycline-induced cutaneous hyperpigmentation. Clin. Exp. Dermatol. 2004, 29, 8–14. [Google Scholar] [CrossRef]
- Okada, N.; Sato, S.; Sasou, T.; Aoyama, M.; Nishida, K.; Yoshikawa, K. Characterization of pigmented granules in minocycline-induced cutaneous pigmentation: Observations using fluorescence microscopy and high-performance liquid chromatography. Br. J. Dermatol. 1993, 129, 403–407. [Google Scholar] [CrossRef]
- Asakura, T.; Nukaga, S.; Namkoong, H.; Yagi, K.; Suzuki, S.; Ishii, M.; Tasaka, S.; Betsuyaku, T.; Hasegawa, N. Blue–Black Trachea as a Result of Minocycline-induced Hyperpigmentation. Am. J. Respir. Crit. Care Med. 2016, 193, e5–e6. [Google Scholar] [CrossRef]
- Ayangco, L.; Sheridan, P.J. Minocycline-Induced Staining of Torus Palatinus and Alveolar Bone. J. Periodontol. 2003, 74, 669–671. [Google Scholar] [CrossRef]
- Sabroe, R.; Archer, C.; Harlow, D.; Bradfield, J.; Peachey, R. Minocycline-induced discolouration of the sclerae. Br. J. Dermatol. 1996, 135, 314–316. [Google Scholar] [CrossRef]
- Reid, J.D. The Black Thyroid Associated with Minocycline Therapy: A Local Manifestation of a Drug-induced Lysosome/Substrate Disorder. Am. J. Clin. Pathol. 1983, 79, 738–746. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Fernandez-Flores, A.; Nguyen, T.; Cassarino, D.S. Mucocutaneous Hyperpigmentation in a Patient with a History of Both Minocycline and Silver Ingestion. Am. J. Dermatopathol. 2017, 39, 916–919. [Google Scholar] [CrossRef] [PubMed]
- Argenyi, Z.B.; Finelli, L.; Bergfeld, W.F.; Tuthill, R.J.; McMahon, J.T.; Ratz, J.L.; Petroff, N. Minocycline-Related Cutaneous Hyperpigmentation as Demonstrated by Light Microscopy, Electron Microscopy and X-Ray Energy Spectroscopy. J. Cutan. Pathol. 1987, 14, 176–180. [Google Scholar] [CrossRef]
- Fay, B.T.; Whiddon, A.P.; Puumala, S.; Black, N.A.; O’dellJ, R.; Mikuls, T.R. Minocycline-Induced Hyperpigmentation in Rheumatoid Arthritis. JCR J. Clin. Rheumatol. 2008, 14, 17–20. [Google Scholar] [CrossRef] [PubMed]
- Mehrany, K.; Kist, J.M.; Ahmed, D.D.F.; Gibson, L.E. Minocycline-induced cutaneous pigmentation. Int. J. Dermatol. 2003, 42, 551–552. [Google Scholar] [CrossRef]
- Roberts, G.; Capell, H.A. The frequency and distribution of minocycline induced hyperpigmentation in a rheumatoid arthritis population. J. Rheumatol. 2006, 33, 1254–1257. [Google Scholar] [PubMed]
- Simon, F.; Oberhuber, A.; Floros, N.; Düppers, P.; Schelzig, H.; Duran, M. Pathophysiology of chronic limb ischemia. Gefässchirurgie 2018, 23, 13–18. [Google Scholar] [CrossRef] [Green Version]
- Franz, R.W.; Jump, M.A.; Spalding, M.C.; Jenkins, J.J. Accuracy of Duplex Ultrasonography in Estimation of Severity of Peripheral Vascular Disease. Int. J. Angiol. 2013, 22, 155–158. [Google Scholar] [Green Version]
- Nisar, M.S.; Iyer, K.; Brodell, R.T.; Lloyd, J.R.; Shin, T.M.; Ahmad, A. Minocycline-induced hyperpigmentation: Comparison of 3 Q-switched lasers to reverse its effects. Clin. Cosmet. Investig. Derm. 2013, 6, 159–162. [Google Scholar]
- Sasaki, K.; Ohshiro, T.; Ohshiro, T.; Sakio, R.; Fukazawa, E.; Toriumi, M.; Ebihara, T. Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser—A case report. Laser Therapy 2017, 26, 137–144. [Google Scholar] [CrossRef]
- Kalia, S.; Adams, S.P. Dermacase Minocycline-Induced Pigmentation. Can. Fam. Physician 2006, 52, 595–596. [Google Scholar] [PubMed]
Type | Skin Color | Pigmentation Pattern | Localization | Histological Finding |
---|---|---|---|---|
Type I | Blue-gray to black | Circumscribed | Face, inflammation area | Pigment location in dermis |
Type II | Blue-gray | Circumscribed | Legs, forearms, hands | Pigment location in dermis/hypodermis |
Type III | Muddy brown | Diffuse | Sun-exposed skin | Pigment location in dermis/epidermis |
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Wu, M.-Y.; Hou, Y.-T.; Yiang, G.-T.; Tsai, A.P.-Y.; Lin, C.-H. Severe Type of Minocycline-Induced Hyperpigmentation Mimicking Peripheral Arterial Occlusive Disease in a Bullous Pemphigoid Patient. Antibiotics 2019, 8, 93. https://doi.org/10.3390/antibiotics8030093
Wu M-Y, Hou Y-T, Yiang G-T, Tsai AP-Y, Lin C-H. Severe Type of Minocycline-Induced Hyperpigmentation Mimicking Peripheral Arterial Occlusive Disease in a Bullous Pemphigoid Patient. Antibiotics. 2019; 8(3):93. https://doi.org/10.3390/antibiotics8030093
Chicago/Turabian StyleWu, Meng-Yu, Yueh-Tseng Hou, Giou-Teng Yiang, Andy Po-Yi Tsai, and Ching-Hsiang Lin. 2019. "Severe Type of Minocycline-Induced Hyperpigmentation Mimicking Peripheral Arterial Occlusive Disease in a Bullous Pemphigoid Patient" Antibiotics 8, no. 3: 93. https://doi.org/10.3390/antibiotics8030093
APA StyleWu, M. -Y., Hou, Y. -T., Yiang, G. -T., Tsai, A. P. -Y., & Lin, C. -H. (2019). Severe Type of Minocycline-Induced Hyperpigmentation Mimicking Peripheral Arterial Occlusive Disease in a Bullous Pemphigoid Patient. Antibiotics, 8(3), 93. https://doi.org/10.3390/antibiotics8030093