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Phage Therapy with a Focus on the Human Microbiota

1
School of Biomedical Engineering, McMaster University, Hamilton, ON L8S 4K1, Canada
2
Department of Chemical Engineering, McMaster University, Hamilton, ON L8S 4L7, Canada
3
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4K1, Canada
4
Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada
*
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(3), 131; https://doi.org/10.3390/antibiotics8030131
Received: 5 July 2019 / Revised: 14 August 2019 / Accepted: 23 August 2019 / Published: 27 August 2019
(This article belongs to the Special Issue Bacteriophages: Alternatives to Antibiotics and Beyond)
Bacteriophages are viruses that infect bacteria. After their discovery in the early 1900s, bacteriophages were a primary cure against infectious disease for almost 25 years, before being completely overshadowed by antibiotics. With the rise of antibiotic resistance, bacteriophages are being explored again for their antibacterial activity. One of the critical apprehensions regarding bacteriophage therapy, however, is the possibility of genome evolution, development of phage resistance, and subsequent perturbations to our microbiota. Through this review, we set out to explore the principles supporting the use of bacteriophages as a therapeutic agent, discuss the human gut microbiome in relation to the utilization of phage therapy, and the co-evolutionary arms race between host bacteria and phage in the context of the human microbiota. View Full-Text
Keywords: microbiome therapy; phage therapy; evolution; antibiotic resistance microbiome therapy; phage therapy; evolution; antibiotic resistance
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MDPI and ACS Style

Divya Ganeshan, S.; Hosseinidoust, Z. Phage Therapy with a Focus on the Human Microbiota. Antibiotics 2019, 8, 131.

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