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Open AccessArticle

Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria

1
Technology Center, Faculty of Technology Cariri, Juazeiro do Norte 63041-190, Brazil
2
Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil
3
Faculty of Medicine of Juazeiro do Norte, Juazeiro do Norte 63041-190, Brazil
*
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(1), 28; https://doi.org/10.3390/antibiotics8010028
Received: 8 February 2019 / Revised: 7 March 2019 / Accepted: 15 March 2019 / Published: 17 March 2019
(This article belongs to the Section Mechanism and Evolution of Antibiotic Resistance)
Orbignya speciosa (babassu) is an important palm tree in Brazil whose fixed almond oil is used in popular medicine and especially in food, in addition to being a research target for the manufacture of biofuels. The aim of this study was to evaluate the fixed almond oil physicochemical characterization and its antibacterial activity in isolation and in association with aminoglycosides against standard and multidrug-resistant bacteria. Analyses such as water content, pH, acidity, peroxide index, relative density, and refractive index indicate the stability and chemical quality of the oil. In the oil’s GC/MS chemical composition analysis, a high saturated fatty acid (76.90%) content was observed. Lauric acid (56.28%) and oleic acid (23.10%) were the major oil components. In the antibacterial test, a more significant oil activity was observed against K. pneumoniae KP-ATCC 10031 (minimal inhibitory concentration (MIC) = 406.37 μg/mL) and Staphylococcus aureus ATCC 6538 (MIC = 812.75 μg/mL), but for the other strains—including standard and multi-resistant strains—the oil presented an MIC ≥ 1024 μg/mL. Furthermore, a synergistic effect was observed when the oil was associated with amikacin and gentamicin against S. aureus (SA-10) and an antagonistic effect was observed with amikacin against Escherichia coli. Data indicate the O. speciosa oil as a valuable nutritional source of lauric, oleic, and myristic fatty acids with an ability to modulate aminoglycoside activity. View Full-Text
Keywords: Orbignya speciosa; babassu; fatty acid; anti-bacterial; aminoglycosides Orbignya speciosa; babassu; fatty acid; anti-bacterial; aminoglycosides
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Machado, J.F.; do Socorro Costa, M.; Tintino, S.R.; Rodrigues, F.F.G.; Nobre, C.B.; Coutinho, H.D.M.; da Costa, J.G.M.; de Menezes, I.R.A.; de Sousa, E.O. Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria. Antibiotics 2019, 8, 28.

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