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Antibiotics 2018, 7(3), 55;

Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications

Department of Chemistry, University College London, London WC1H 0AJ, UK
European Bioenergy Research Institute, Aston University, Birmingham B4 7ET, UK
Inorganic Chemistry and Catalysis, Debye Institute for Nanomaterials Science, Utrect University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Sincrotrone Trieste, 34149 Basovizza, Italy
School of Science, RMIT University, Melbourne, VIC 3001, Australia
Authors to whom correspondence should be addressed.
Received: 22 June 2018 / Revised: 28 June 2018 / Accepted: 2 July 2018 / Published: 3 July 2018
(This article belongs to the Special Issue Silver-Based Antimicrobials)
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Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag2CO3 formation and the release of ionic silver in simulated tissue fluid. The Ag2CO3 concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA). View Full-Text
Keywords: silver; antibacterial; titania; mesoporous; macroporous; surface functionalization silver; antibacterial; titania; mesoporous; macroporous; surface functionalization

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Isaacs, M.A.; Barbero, B.; Durndell, L.J.; Hilton, A.C.; Olivi, L.; Parlett, C.M.A.; Wilson, K.; Lee, A.F. Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications. Antibiotics 2018, 7, 55.

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