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Antibiotics
Volume 14
Issue 7
10.3390/antibiotics14070666
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Case Report

Congenital Candida krusei Sepsis in an Extremely Preterm Baby: Case Report and Literature Review

by
Francesca Cossovel
1,*,
Silvia Nider
1,
Jenny Bua
1,
Elena Ghirigato
2,
Monica Piccoli
3,
Paolo Manzoni
4 and
Laura Travan
1
1
Department of Neonatology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy
2
Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy
3
Department of Obstetrics and Gynecology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy
4
Department of Pediatrics and Neonatology, University Hospital Degli Infermi, 13875 Biella, Italy
*
Author to whom correspondence should be addressed.
Antibiotics 2025, 14(7), 666; https://doi.org/10.3390/antibiotics14070666
Submission received: 3 May 2025 / Revised: 23 June 2025 / Accepted: 23 June 2025 / Published: 30 June 2025
(This article belongs to the Special Issue Neonatal Infections: Epidemiology, Diagnostics and Antibiotic Therapeutics)
Versions Notes

Abstract

A preterm neonate born at 24 + 5 weeks gestation developed congenital Candida krusei sepsis, diagnosed via placental culture, axillary swab, and elevated beta-glucan levels. Although initial blood cultures were negative, continuous HeRo monitoring played a crucial role in the early detection of clinical deterioration, prompting timely antifungal therapy with amphotericin B followed by micafungin. This proactive approach, combining prompt diagnosis, HeRo surveillance, and tailored treatment, ensured a favorable outcome. Our case underscores the value of HeRo monitoring as an early warning tool in managing neonatal fungal infections.
Keywords: congenital candida; Candida krusei; preterm baby congenital candida; Candida krusei; preterm baby

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MDPI and ACS Style

Cossovel, F.; Nider, S.; Bua, J.; Ghirigato, E.; Piccoli, M.; Manzoni, P.; Travan, L. Congenital Candida krusei Sepsis in an Extremely Preterm Baby: Case Report and Literature Review. Antibiotics 2025, 14, 666. https://doi.org/10.3390/antibiotics14070666

AMA Style

Cossovel F, Nider S, Bua J, Ghirigato E, Piccoli M, Manzoni P, Travan L. Congenital Candida krusei Sepsis in an Extremely Preterm Baby: Case Report and Literature Review. Antibiotics. 2025; 14(7):666. https://doi.org/10.3390/antibiotics14070666

Chicago/Turabian Style

Cossovel, Francesca, Silvia Nider, Jenny Bua, Elena Ghirigato, Monica Piccoli, Paolo Manzoni, and Laura Travan. 2025. "Congenital Candida krusei Sepsis in an Extremely Preterm Baby: Case Report and Literature Review" Antibiotics 14, no. 7: 666. https://doi.org/10.3390/antibiotics14070666

APA Style

Cossovel, F., Nider, S., Bua, J., Ghirigato, E., Piccoli, M., Manzoni, P., & Travan, L. (2025). Congenital Candida krusei Sepsis in an Extremely Preterm Baby: Case Report and Literature Review. Antibiotics, 14(7), 666. https://doi.org/10.3390/antibiotics14070666

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