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Antibiotics
Volume 14
Issue 6
10.3390/antibiotics14060620
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

First Report in the Americas of S. enterica Var. Enteritidis Carrying blaNDM-1 in a Putatively New Sub-Lineage of IncC2 Plasmids

by
Nicolás F. Cordeiro
1,
Romina Papa-Ezdra
1,
Germán Traglia
2,
Inés Bado
1,
Virginia García-Fulgueiras
1,
María N. Cortinas
3,
Leticia Caiata
3,
Mariana López-Vega
3,
Ana Otero
3,
Martín López
4,
Patricia Hitateguy
4,
Cristina Mogdasy
3 and
Rafael Vignoli
1,*
1
Unidad Académica de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Av. Alfredo Navarro 3051, Montevideo 11600, Uruguay
2
Unidad de Genómica y Bioinformática, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Uni versidad de la República, Salto 50000, Uruguay
3
Departamentos de Laboratorios de Salud Pública, Ministerio de Salud Pública, Montevideo 11600, Uruguay
4
Sanatorio Círculo Católico, Montevideo 11800, Uruguay
*
Author to whom correspondence should be addressed.
Antibiotics 2025, 14(6), 620; https://doi.org/10.3390/antibiotics14060620
Submission received: 9 May 2025 / Revised: 16 June 2025 / Accepted: 17 June 2025 / Published: 18 June 2025
(This article belongs to the Special Issue Multidrug-Resistance Patterns in Infectious Pathogens)
Versions Notes

Abstract

Background: Infections caused by carbapenem-resistant Enterobacterales have steadily multiplied over time, becoming a major threat to healthcare systems due to limited therapeutic options and high case-fatality rates. Case report: We studied a patient who, after being discharged from an ICU, developed salmonellosis caused by an antibiotic-susceptible S. enteritidis. After undergoing treatment with ciprofloxacin, the patient presented an episode of asymptomatic bacteriuria originated by a carbapenem and ciprofloxacin-resistant S. enteritidis. Results: Whole genome sequencing analysis revealed that both Salmonella isolates belonged to the same strain, and that isolate SEn_T2 acquired a plasmid carrying both blaNDM-1 and qnrA1 genes (pIncCSEn) which was previously present in the patient’s gut in at least one Enterobacter cloacae isolate. Additionally, pIncCSEN was identified as a putatively new sub-lineage of IncC2 plasmids which lacked the first copy of the methyltransferase gene dcm and the rhs gene. The resistance genes blaNDM-1 and qnrA1 were incorporated into a Tn21-derived transposon that included a complex class 1 integron whose genetic arrangement was: intI1- dfrA12- orfF- aadA2- qacEΔ1-sul1-ISCR1- trpF- ble- blaNDM-1 (in reverse direction)- ISAba125-ISCR1- qnrA- cmlA1- qacEΔ1-sul1. Conclusions: Antimicrobial persistence and co-selection of antibiotic resistance play an important role in the dissemination of antimicrobial resistance genes; in this regard, a joint effort involving the infection control team, effective antibiotic stewardship, and genomic surveillance could help mitigate the spread of these multidrug resistant microorganisms.
Keywords: carbapenemases; antimicrobial resistance; NDM-1; Salmonella enterica; transposon carbapenemases; antimicrobial resistance; NDM-1; Salmonella enterica; transposon

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MDPI and ACS Style

Cordeiro, N.F.; Papa-Ezdra, R.; Traglia, G.; Bado, I.; García-Fulgueiras, V.; Cortinas, M.N.; Caiata, L.; López-Vega, M.; Otero, A.; López, M.; et al. First Report in the Americas of S. enterica Var. Enteritidis Carrying blaNDM-1 in a Putatively New Sub-Lineage of IncC2 Plasmids. Antibiotics 2025, 14, 620. https://doi.org/10.3390/antibiotics14060620

AMA Style

Cordeiro NF, Papa-Ezdra R, Traglia G, Bado I, García-Fulgueiras V, Cortinas MN, Caiata L, López-Vega M, Otero A, López M, et al. First Report in the Americas of S. enterica Var. Enteritidis Carrying blaNDM-1 in a Putatively New Sub-Lineage of IncC2 Plasmids. Antibiotics. 2025; 14(6):620. https://doi.org/10.3390/antibiotics14060620

Chicago/Turabian Style

Cordeiro, Nicolás F., Romina Papa-Ezdra, Germán Traglia, Inés Bado, Virginia García-Fulgueiras, María N. Cortinas, Leticia Caiata, Mariana López-Vega, Ana Otero, Martín López, and et al. 2025. "First Report in the Americas of S. enterica Var. Enteritidis Carrying blaNDM-1 in a Putatively New Sub-Lineage of IncC2 Plasmids" Antibiotics 14, no. 6: 620. https://doi.org/10.3390/antibiotics14060620

APA Style

Cordeiro, N. F., Papa-Ezdra, R., Traglia, G., Bado, I., García-Fulgueiras, V., Cortinas, M. N., Caiata, L., López-Vega, M., Otero, A., López, M., Hitateguy, P., Mogdasy, C., & Vignoli, R. (2025). First Report in the Americas of S. enterica Var. Enteritidis Carrying blaNDM-1 in a Putatively New Sub-Lineage of IncC2 Plasmids. Antibiotics, 14(6), 620. https://doi.org/10.3390/antibiotics14060620

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