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Antibiotics
Volume 12
Issue 7
10.3390/antibiotics12071214
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Article
Peer-Review Record

Real-Life Experience of Continuously Infused Ceftolozane/Tazobactam in Patients with Bronchiectasis and Multidrug-Resistant Pseudomonas aeruginosa Infection in the Outpatient Setting

Antibiotics 2023, 12(7), 1214; https://doi.org/10.3390/antibiotics12071214
by Francesco Venuti 1, Alberto Gaviraghi 1, Amedeo De Nicolò 2, Giacomo Stroffolini 3, Bianca Maria Longo 1, Alessia Di Vincenzo 2, Fabio Antonino Ranzani 1, Matilde Quaranta 1, Francesca Romano 1, Eleonora Catellani 4, Carlotta Marchiaro 4, Giacoma Cinnirella 4, Antonio D’Avolio 2, Stefano Bonora 1 and Andrea Calcagno 1,*
Reviewer 1: Anonymous
Antibiotics 2023, 12(7), 1214; https://doi.org/10.3390/antibiotics12071214
Submission received: 19 June 2023 / Revised: 17 July 2023 / Accepted: 18 July 2023 / Published: 21 July 2023
(This article belongs to the Special Issue Current Trends, Recent Advances and Applications of Outpatient Parenteral Antimicrobial Therapy (OPAT))

Round 1

Reviewer 1 Report

 

Venuti F. et al. is a report describing results from a retrospective study of continuously infused ceftolozone/tazobactam using elastomeric pumps in 3 patients with bronchiectasis and MDR-pseudomonas aeruginosa infection in the outpatient setting.

My comments are as follows:

1.      Page 3 Line 106: I suggest to provide a reference for the protein binding approximations for ceftolozone/tazobactam

2.      I would recommend adding information on pharmacokinetics of ceftolozone/tazobactam in the introduction section including their respective half-life

3.      I suggest reducing the discussion section to focus on how the findings from the current study advance the current knowledge of the subject and only briefly discuss relevant published literature.

4.      I suggest to clarify the duration of treatment in the methods section

5.      Figure 1: Why do the X and Y-axis value include (“) at the end? Suggest adding units for time on the X-axis label. Also the figure legend (both in the plot and the text below) has several typos and spelling mistakes which need to be fixed

Page 6 Line 201: For numbers described in the text use ‘.’ Instead of ‘,’ in all places to identify decimal digits

 

 

 

Please correct spelling mistakes and typos throughout the manuscript. Some examples below:

Page 7 line 223: ‘Bactericidal’ and ‘activity’ spellings need to be corrected.

Page 5 Line 163: Change form to from

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The authors should describe poperly which software were employed in order to model PK/PD data, as well, variations of models tested in order of evaluation can be done

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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