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Antibiotics
Volume 12
Issue 1
10.3390/antibiotics12010053
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Case Report
Peer-Review Record

A Clinical Case of Nosocomial Pneumonia as a Complication of COVID-19: How to Balance Benefits and Risks of Immunosuppressive Therapy?

Antibiotics 2023, 12(1), 53; https://doi.org/10.3390/antibiotics12010053
by Svetlana Rachina 1,*, Gairat Kiyakbaev 1, Elena Antonova 2, Alexey Mescheryakov 2, Olga Kupryushina 1, Girindu Hewathanthirige 3, Ivan Palagin 4, Elena Kozhevnikova 2, Marina Sukhorukova 5 and Daria Strelkova 1
Reviewer 1: Anonymous
Reviewer 2:
Gee Jun Tye
Reviewer 3: Anonymous
Antibiotics 2023, 12(1), 53; https://doi.org/10.3390/antibiotics12010053
Submission received: 14 November 2022 / Revised: 20 December 2022 / Accepted: 27 December 2022 / Published: 29 December 2022
(This article belongs to the Special Issue Antimicrobials and Antimicrobial Resistance: Current and Future Prospects)

Round 1

Reviewer 1 Report

I feel that this case, even if it is well written, is of very little use to readers. The picture of pneumonia could be totally attributable to COVID and the isolated microorganisms could only be colonizers

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

The case study presented by the authors is very interesting as it addresses the need for attention to nosocomial infections in COVID-19 especially as it is now endemic and would be presented as a good study for future treatment. I have a few suggestions that could be considered by authors.

1. Case presentation could be separated to "case presentation" and "management and outcome" in order to help readers to better understand.

2. There are some formatting error e.g. line 151

3. Cytokine storm is normally the cause of damaged tissues in COVID-19. Can the authors discuss about it in the discussion as it was only mentioned in case presentation but not in the discussion.

 

Thank you

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

Authors have presented only 1 case of nosocomial pneumonia (NP) in COVID-19 and hence it is possible authors observations could be improved with examining more cases and comparing with cases where NP was not seen. If authors cannot include more studies or literature comparison, the manuscript title should reflect the speculation in this study.

Lines 38-41 = Authors assume effect of excessive or inappropriate prescription of antibiotics including others are the main trigger of NP. A literature search might give more examples which support or counter author insights. 

Lines 144-145 = Could authors provide possible mechanism of "aggressive" immunotherapy induced contribution for NP and lung abscess development.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

The paper has been improved and can now be accepted

 

Reviewer 3 Report

Authors have satisfactorily answered my comments.

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