Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus
Abstract
:1. Introduction
2. Compounds with Diverse Structures
2.1. Polyphenol Compounds
2.2. Triterpenoids
2.3. Fatty Acid Compounds
2.4. Miscellaneous Compounds
3. Biological and Pharmacological Activities
3.1. Antitumor Activity
3.2. Antioxidant Activity
3.3. Antimicrobial Activity
3.4. Neurotrophic and Neuroprotective Activity
3.5. Enzyme Inhibitory Activity
3.6. Immunomodulatory Effects and Other Biological activities
4. Biosynthetic Progresses on Styrylpyrones
5. Discussions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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No. | Name | Resource | Method | Activity | Reference |
---|---|---|---|---|---|
1 | hispidin | fruiting body, mycelium | EtOH, MeOH | Antitumor, ABTS, DPPH, influenza A and B viruses, Enzyme-inhibitory, antineurodegenerative | Edwards et al. [9]. Zan et al. [15]. Ali, N.A.A. et al. [29]. Zan et al. [16]. Zan et al. [30]. Benarous, K. et al. [31]. Benarous, K. et al. [32]. Gruendemann, C. et al. [17]. |
2 | Bis-noryangonin | mycelium | NA | NA | Perrin, P.W.et al. [10]. |
3 | hypholomin B | fruiting body | NA | NA | Fiasson et al. [11]. |
4 | 3,14’-bishispidinyl | fruiting body | MeOH | NA | Fiasson et al. [11]. Ren et al. [18]. |
5 | hispolon | fruiting body mycelium | EtOH, MeOH EAC | DPPH, influenza A and B viruses, PC-12 cell, BV-2 microglia, ntineurodegenerative | Nasser Ali et al. [12]. Zan et al. [15]. Tang et al. [22]. Kou et al. [21]. Ali, N.A.A. et al. [29]. Gruendemann, C. et al. [17]. |
6 | methyl 5-(3,4-dihydroxyphenyl)-3-hydroxypenta-2,4-dienoate | fruiting body | MeOH | NA | Yousfi et al. [13]. |
7 | inonotusin A | fruiting body | MeOH | MCF-7, ABTS | Zan et al. [15]. Zan et al. [16]. |
8 | inonotusin B | fruiting body | MeOH | Antitumor, ABTS | Zan et al. [15]. Zan et al. [16]. |
9 | osmundacetone | fruiting body | MeOH | DPPH, PC-12 cell, BV-2 microglia | Zan et al. [15]. Kou et al. [21]. |
10 | protocatechualdehyde | fruiting body | MeOH | NA | Zan et al. [15]. |
11 | inoscavin C | fruiting body | MeOH | NA | Zan et al. [15]. |
12 | inoscavin D | fruiting body | MeOH | NA | Zan et al. [15]. |
13 | protocatechuic acid | fruiting body | MeOH | NA | Zan et al. [15]. |
14 | hispinine | fruiting body | MeOH | NA | Ren et al. [18]. |
15 | pinillidine | fruiting body | MeOH | NA | Ren et al. [18]. |
16 | 3’4’-dihydroxy-5-[11-hydroxyphenyl]-6,7-vinyl]-3,5-dioxafluoren-5-one | fruiting body | EtOH | mouse macrophage cell | Li et al. [2]. |
17 | phelligridin C | fruiting body | EtOH | NA | Li et al. [2]. |
18 | phellibaumin A | fruiting body | EtOH MeOH | mouse macrophage cell | Li et al. [2]. Yang et al. [20]. |
19 | phelligridin C’ | fruiting body | EtOH | NA | Li et al. [2]. |
20 | phelligridin D | fruiting body | EtOH | mouse macrophage cell | Li et al. [2]. |
21 | MBP | fruiting body | MeOH | HepG2, MCF-7, Hela and A549 cells | Yang et al. [20]. |
22 | inonophenol A | fruiting body | MeOH | DPPH, PC-12 cell, BV-2 microglia | Kou et al. [21]. |
23 | inonophenol B | fruiting body | MeOH | DPPH, PC-12 cell, BV-2 microglia | Kou et al. [21]. |
24 | inonophenol C | fruiting body | MeOH | DPPH, PC-12 cell, BV-2 microglia | Kou et al. [21]. |
25 | 4-(3′,4′-dihydroxyphenyl)-2-butanone | fruiting body | MeOH | DPPH, PC-12 cell, BV-2 microglia | Kou et al. [21]. |
26 | 3β, 22-dihydroxy-lanosta-8,24-diene | fruiting body | EtOH | U937, Hela, QRH-7701 | Yang et al. [23]. |
27 | ergosterol | fruiting body mycelium | EtOH, MeOH EAC | NA | Yang et al. [23]. Zan et al. [15]. Tang et al. [22]. |
28 | ergosterol-5,8-peroxide | fruiting body | EtOH, MeOH | BV-2 microglia | Yang et al. [23]. Zan et al. [15]. Kou et al. [21]. |
29 | eburicoic acid | fruiting body | EtOH, MeOH | NA | Yang et al. [23]. Zan et al. [15]. |
30 | 7(8),22(23)-dien-3-one-ergostane | fruiting body | MeOH | NA | Zan et al. [15]. |
31 | 4,6,8(14),22(23)-tetraen-3-one-ergostane | fruiting body | MeOH | NA | Zan et al. [15]. |
32 | hispindic acid A | fruiting body | MeOH | NA | Ren et al. [18]. |
33 | hispindic acid B | fruiting body | MeOH | NA | Ren et al. [18]. |
34 | inotolactone B | fruiting body | MeOH | B16 melanoma cell | Ren et al. [18]. |
35 | ergosterol-3-O-β-D-glucopyranoside | fruiting body | MeOH | BV-2 microglia | Ren et al. [18]. Kou et al. [21]. |
36 | 24-methylenelanost-8-en-3β-ol | fruiting body | MeOH | BV-2 microglia | Kou et al. [21]. |
37 | cerevisterol | fruiting body | MeOH | NA | Kou et al. [21]. |
38 | (22E, 24R)-ergosta-7,22-diene-3β,5α,6β,9α-tetrol | fruiting body | MeOH | NA | Kou et al. [21]. |
39 | Inonoterpene A | fruiting body | MeOH | BV-2 microglia | Kou et al. [21]. |
40 | 3β-hydroxy-lanosta-8,24-dien-21-al | fruiting body | MeOH | BV-2 microglia | Kou et al. [21]. |
41 | hexadecanoic acid | fruiting body | EtOH, MeOH | NA | Yang et al. [23]. Zan et al. [15]. |
42 | octadecanoic acid | fruiting body | EtOH | NA | Yang et al. [23]. |
43 | (E)-9-hexadecenoic acid methyl ester | fruiting body | MeOH | NA | Zan et al. [15]. |
44 | hexadecanoic acid methyl ester | fruiting body | MeOH | NA | Zan et al. [15]. |
45 | hexadecanoic acid ethyl ester | fruiting body | MeOH | NA | Zan et al. [15]. |
46 | 10,13-octadecadienoic acid methyl ester | fruiting body | MeOH | NA | Zan et al. [15]. |
47 | ethyl oleate | fruiting body | MeOH | NA | Zan et al. [15]. |
48 | linoleic acid ethyl ester | fruiting body | MeOH | NA | Zan et al. [15]. |
49 | 9,12-octadecadienoic acid (Z, Z)-methyl ester | fruiting body | MeOH | NA | Zan et al. [15]. |
50 | Isopropyl linoleate | fruiting body | MeOH | NA | Zan et al. [15]. |
51 | cis-erucic acid | fruiting body | MeOH | NA | Zan et al. [15]. |
52 | cis-9,17 octadecadienoic acid methyl ester | fruiting body | MeOH | NA | Zan et al. [15]. |
53 | phenylalaninopine | fruiting body | Water | NA | Politi et al. [25]. |
54 | D-arabitol | fruiting body | EtOH | NA | Yang et al. [23]. |
55 | D-glucose | fruiting body | EtOH | NA | Yang et al. [23]. |
56 | squalene | fruiting body | MeOH | NA | Zan et al. [15]. |
57 | docosane | fruiting body | MeOH | NA | Zan et al. [15]. |
58 | 1,2-benzenedicarboxylic acid mono(2-ethylhexyl) ester | fruiting body | MeOH | NA | Zan et al. [15]. |
59 | HDE | fruiting body | MeOH | HepG2, McF-7, Hela, A549 and H22 cells | Yang et al. [27]. |
60 | inosine | fruiting body | MeOH | NA | Yang et al. [20]. |
61 | xylaritriol | fruiting body | MeOH | BV-2 microglia | Kou et al. [21]. |
62 | cinnamic acid | mycelium | NA | NA | Tang et al. [22]. |
63 | uridine | mycelium | NA | NA | Tang et al. [22]. |
64 | Cyclo (L-Leu-L-Phe) | mycelium | NA | NA | Tang et al. [22]. |
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Wang, Z.-x.; Feng, X.-l.; Liu, C.; Gao, J.-m.; Qi, J. Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus. Antibiotics 2022, 11, 1097. https://doi.org/10.3390/antibiotics11081097
Wang Z-x, Feng X-l, Liu C, Gao J-m, Qi J. Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus. Antibiotics. 2022; 11(8):1097. https://doi.org/10.3390/antibiotics11081097
Chicago/Turabian StyleWang, Zhen-xin, Xi-long Feng, Chengwei Liu, Jin-ming Gao, and Jianzhao Qi. 2022. "Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus" Antibiotics 11, no. 8: 1097. https://doi.org/10.3390/antibiotics11081097